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WAY 316606 hydrochloride

Cat. No. 4767 1 Citation 1 Review Submit a Review Datasheet / COA / SDS
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Description: Secreted Frizzled-related protein-1 (sFRP-1) inhibitor; increases Wnt signaling
Chemical Name: 5-(Phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)benzene sulfonamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for WAY 316606 hydrochloride

WAY 316606 hydrochloride is a secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC50 = 0.65 μM); prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. Increases total bone area in a murine calvarial organ culture assay.

We are aware of a study in PLOS Biology where WAY-316606 was found to stimulate hair follicle growth. Please note that WAY-316606 from Tocris is for laboratory research use only, and that we will only sell to established scientific businesses and institutes.

Compound Libraries for WAY 316606 hydrochloride

WAY 316606 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for WAY 316606 hydrochloride

M. Wt 484.94
Formula C18H19F3N2O4S2.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1781835-02-6
PubChem ID 25186563
InChI Key YLOYHLUHXQJNGO-UHFFFAOYSA-N
Smiles O=S(C1=CC=C(C(F)(F)F)C(S(NC3CCNCC3)(=O)=O)=C1)(C2=CC=CC=C2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WAY 316606 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.7 20

Preparing Stock Solutions for WAY 316606 hydrochloride

The following data is based on the product molecular weight 484.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.31 mL 51.55 mL 103.11 mL
1 mM 2.06 mL 10.31 mL 20.62 mL
2 mM 1.03 mL 5.16 mL 10.31 mL
10 mM 0.21 mL 1.03 mL 2.06 mL

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Product Datasheets for WAY 316606 hydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for WAY 316606 hydrochloride

References are publications that support the biological activity of the product.

Moore et al (2010) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. Bioorg.Med.Chem. 18 190 PMID: 19932972

Moore et al (2009) Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J.Med.Chem. 52 105 PMID: 19072540

Bodine et al (2009) A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone 44 1063 PMID: 19254787

If you know of a relevant reference for WAY 316606 hydrochloride, please let us know.

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Keywords: WAY 316606 hydrochloride, WAY 316606 hydrochloride supplier, WAY316606, hydrochloride, CAS, [915759-45-4], Bone, osteoporosis, secreted, frizzled-related, protein-1, sFRP-1, inhibitors, inhibits, Wnt, signaling, signalling, Beta-catenin, 4767, Tocris Bioscience

1 Citation for WAY 316606 hydrochloride

Citations are publications that use Tocris products. Selected citations for WAY 316606 hydrochloride include:

Ichijo et al (2017) Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration. Nat Commun 8 508 PMID: 28894084

Do you know of a great paper that uses WAY 316606 hydrochloride from Tocris? Please let us know.

Reviews for WAY 316606 hydrochloride

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Exactly what it is supposed to be..
By Anonymous on 06/28/2020
Species: Human

We are a reference lab and needed to compare a questioned product to authentic WAY-316606. We generated our own purity and identity information on this product and confirmed the COA. The attached PDF shows that the infrared spectrum was an exact match with the questioned material. That's exactly what we needed to confirm.

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Pathways for WAY 316606 hydrochloride

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.