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Submit ReviewWAY 629 hydrochloride
Description: Selective 5-HT2C agonist
Chemical Name: 1,2,3,4,8,9,10,11-Octahydro[1,4]diazepino[6,7,1-jk]carbazole hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for WAY 629 hydrochloride
Selective 5-HT2C agonist. Ki values are 56, 2350, 1575 and 815 nM for human recombinant 5-HT2C, 5-HT2A, 5-HT6 and 5-HT7 receptors respectively. Stimulates intracellular Ca2+ mobilization in CHO cells expressing human 5-HT2C receptors (EC50 = 72 nM). Reduces food intake in rats.
Technical Data for WAY 629 hydrochloride
| M. Wt | 262.78 |
| Formula | C15H18N2.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 57756-44-2 |
| PubChem ID | 12259556 |
| InChI Key | PZXUJERSOFOWES-UHFFFAOYSA-N |
| Smiles | Cl.C1CCC2=C(C1)N1CCNCC3=C1C2=CC=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for WAY 629 hydrochloride
References for WAY 629 hydrochloride
References are publications that support the biological activity of the product.
Sabb et al (2004) Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor. Bioorg.Med.Chem.Lett. 14 2603 PMID: 15109661
Dunlop et al (2004) Identification of cycloalkyl[b][1,4]benzodiazepinoindoles as novel 5-HT2C receptor agonists. Fund.Clin.Pharmacol. 18 145
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Citations for WAY 629 hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.