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Submit ReviewWIN 64338 hydrochloride
Description: Bradykinin B2 antagonist
Chemical Name: (S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride
Biological Activity for WIN 64338 hydrochloride
WIN 64338 hydrochloride is a the first potent, non-peptide, competitive bradykinin B2 receptor antagonist. In organ bath studies, WIN 64338 inhibits [3H]-bradykinin binding on guinea pig trachea with nanomolar affinity but is not active in the rabbit aorta (the classical bradykinin B1 preparation).
Technical Data for WIN 64338 hydrochloride
| M. Wt | 783.95 |
| Formula | C45H68ClN4OP.HCl |
| Storage | Desiccate at +4°C |
| CAS Number | 163727-74-0 |
| PubChem ID | 9832172 |
| InChI Key | YYJGBEZPVOUBMJ-KRFCICRISA-N |
| Smiles | CCCC[P+](CCCC)(CC1=CC=C(C=C1)NC([C@@H](/N=C(NC2CCCCC2)/NC3CCCCC3)CC4=CC5=CC=CC=C5C=C4)=O)CCCC.Cl.[Cl-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for WIN 64338 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.8 | 75 |
Preparing Stock Solutions for WIN 64338 hydrochloride
The following data is based on the product molecular weight 783.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 1.7 mL | 8.5 mL | 17.01 mL |
| 3.75 mM | 0.34 mL | 1.7 mL | 3.4 mL |
| 7.5 mM | 0.17 mL | 0.85 mL | 1.7 mL |
| 37.5 mM | 0.03 mL | 0.17 mL | 0.34 mL |
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Product Datasheets for WIN 64338 hydrochloride
References for WIN 64338 hydrochloride
References are publications that support the biological activity of the product.
Hu et al (2004) Action of bradykinin in the submucosal plexus of guinea pig small intestine. J.Pharmacol.Exp.Ther. 309 320 PMID: 14718600
Marceau et al (1994) Effects of peptide and nonpeptide antagonists of bradykinin B2 receptors on the venoconstrictor action of bradykinin. J.Pharmacol.Exp.Ther. 269 1136 PMID: 8014858
Scherrer et al (1995) Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea. Br.J.Pharmacol. 115 1127 PMID: 7582533
If you know of a relevant reference for WIN 64338 hydrochloride, please let us know.
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Keywords: WIN 64338 hydrochloride, WIN 64338 hydrochloride supplier, Bradykinin, B2, antagonists, Receptors, WIN64338, hydrochloride, 1057, Tocris Bioscience
1 Citation for WIN 64338 hydrochloride
Citations are publications that use Tocris products. Selected citations for WIN 64338 hydrochloride include:
Gross et al (2013) Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction. J Cardiovasc Pharmacol Ther 18 38 PMID: 22407888
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