Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewWKYMVm
Description: FPR1, FPR2 and FPR3 receptor agonist
Alternative Names: Leukocyte chemoattractant peptide
Purity: ≥95% (HPLC)
Biological Activity for WKYMVm
WKYMVm is a selective agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM), expressed on immune cells. Induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. Also promotes monocyte survival through a PKC-, PI 3-kinase- and Akt-dependent pathway.
Technical Data for WKYMVm
| M. Wt | 856.11 |
| Formula | C41H61N9O7S2 |
| Sequence |
WKYMVM (Modifications: Met-6 = D-Met & C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 187986-17-0 |
| PubChem ID | 457933 |
| InChI Key | FMBGOORJEKQQLG-JUZZZACGSA-N |
| Smiles | [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for WKYMVm
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for WKYMVm
References for WKYMVm
References are publications that support the biological activity of the product.
Bae et al (2002) The synthetic chemoattractant peptide, Trp-Lys-Tyr-Met-Val-D-Met, enhances monocyte survival via PKC-dependent Akt activation. J.Leukoc.Biol. 71 329 PMID: 11818455
Christophe et al (2001) The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J.Biol.Chem. 276 21585 PMID: 11285256
Le et al (1999) Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and fomyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation. J.Immunol. 163 6777 PMID: 10586077
If you know of a relevant reference for WKYMVm, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: WKYMVm, WKYMVm supplier, FPR1, FPR2, FPR3, receptor, agonists, FPRL, Formyl, like, Peptide, Receptors, Leukocyte, chemoattractant, peptide, 1800, Tocris Bioscience
3 Citations for WKYMVm
Citations are publications that use Tocris products. Selected citations for WKYMVm include:
Khau et al (2011) Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. Invest Ophthalmol Vis Sci 25 483 PMID: 20930115
Thompson et al (2014) Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor: ASSOCIATION WITH CELL PROTECTION FROM APOPTOSIS. J Biol Chem 289 36166 PMID: 25326384
Kienle et al (2021) Neutrophils self-limit swarming to contain bacterial growth in vivo Science 372 1262 PMID: 34140358
Do you know of a great paper that uses WKYMVm from Tocris? Please let us know.
Reviews for WKYMVm
There are currently no reviews for this product. Be the first to review WKYMVm and earn rewards!
Have you used WKYMVm?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image