WNTinib

Cat. No. 8106 Submit a Review Datasheet / COA / SDS

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Description: Inhibitor of mutant β-catenin signaling in hepatocellular carcinoma

Chemical Name: 4-[3-Fluoro-4-[[[[4-(1,1,2,2,2-pentafluoroethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Pathways (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for WNTinib

WNTinib is a multi-kinase inhibitor with selectivity for mutant β-catenin (CTNNB1) in hepatocellular carcinoma compared to wild type hepatocytes (IC₅₀ ranges are 0.36 μM-0.54 μM in primary organoids; 0.28 μM-1 μM in primary human HCC cell lines and 0.45 μM-2.3 μM in human cell lines ). Also inhibits VEGFR2, PDE6D and VEGFR1 (IC₅₀ values are 0.3 μM, 0.3 μM and 0.6 μM respectively). Downregulates WNT and phospho-EZH2, upregulates trimethylation of H3K27 and normalises expression of apoptotic genes.

Technical Data for WNTinib

M. Wt	498.39
Formula	C₂₂H₁₆F₆N₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2770091-44-4
PubChem ID	170535525
InChI Key	URCPDENSDRVZDE-UHFFFAOYSA-N
Smiles	O=C(NC1=CC=C(C=C1F)OC2=CC(C(NC)=O)=NC=C2)NC3=CC=C(C(F)(C(F)(F)F)F)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WNTinib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.84	100

Preparing Stock Solutions for WNTinib

The following data is based on the product molecular weight 498.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.01 mL	10.03 mL	20.06 mL
5 mM	0.4 mL	2.01 mL	4.01 mL
10 mM	0.2 mL	1 mL	2.01 mL
50 mM	0.04 mL	0.2 mL	0.4 mL

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Product Datasheets for WNTinib

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for WNTinib

References are publications that support the biological activity of the product.

Rialdi et al (2023) WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma. Nat.Cancer 4 1157 PMID: 37537299

If you know of a relevant reference for WNTinib, please let us know.

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Keywords: WNTinib, WNTinib supplier, Wnt, beta-catenin, b-catenin, catenin, CTNNB1, mutant, hepatocellular, carcinoma, kinase, inhibitor, inhibitors, Beta-catenin, 8106, Tocris Bioscience

Citations for WNTinib

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Pathways for WNTinib

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.