Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewY-25130 hydrochloride
Description: Potent and selective 5-HT3 antagonist
Chemical Name: N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Y-25130 hydrochloride
Y-25130 hydrochloride is a selective and potent 5-HT3 antagonist (Ki = 2.9 nM).
Technical Data for Y-25130 hydrochloride
| M. Wt | 386.28 |
| Formula | C17H20ClN3O3.HCl |
| Storage | Desiccate at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 123040-16-4 |
| PubChem ID | 115000 |
| InChI Key | DBMKBKPJYAHLQP-UHFFFAOYSA-N |
| Smiles | Cl.CN1C(=O)COC2=C(C=C(Cl)C=C12)C(=O)NC1CN2CCC1CC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Y-25130 hydrochloride
References for Y-25130 hydrochloride
References are publications that support the biological activity of the product.
Fukuda et al (1991) The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist. Eur.J.Pharmacol. 196 299 PMID: 1654255
Haga et al (1993) The effects of orally administered Y-25130, a selective serotonin3 receptor antagonist on chemotherapeutic agent-induced emesis. Jpn.J.Pharmacol. 63 377 PMID: 8107329
Sato et al (1992) Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn.J.Pharmacol. 59 443 PMID: 1331590
View Related Products by Target
View Related Products by Product Action
Keywords: Y-25130 hydrochloride, Y-25130 hydrochloride supplier, Potent, selective, 5-HT3, antagonists, Serotonin, Receptors, 0380, Tocris Bioscience
2 Citations for Y-25130 hydrochloride
Citations are publications that use Tocris products. Selected citations for Y-25130 hydrochloride include:
Sándor et al (2018) Evidence Supports Tradition: The in Vitro Effects of Roman Chamomile on Smooth Muscles. Front Pharmacol 9 323 PMID: 29681854
Xiao et al (2008) Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Proc Natl Acad Sci U S A 4 12 PMID: 18416824
Reviews for Y-25130 hydrochloride
There are currently no reviews for this product. Be the first to review Y-25130 hydrochloride and earn rewards!
Have you used Y-25130 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.