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Submit ReviewYM 90709
Description: Interleukin-5 receptor antagonist
Chemical Name: 5,6-Dihydro-2,3-dimethoxy-6,6-dimethylbenz[7,8]indolizino[2,3-b]quinoxaline
Purity: ≥99% (HPLC)
Biological Activity for YM 90709
YM 90709 is a novel, selective inhibitor of interleukin-5 (IL-5) (IC50 = 0.45 - 1 mM). Inhibits IL-5-prolonged eosinophil survival and IL-5-induced tyrosine phosphorylation of JAK2 without inhibiting GM-CSF-mediated effects. Inhibits antigen-induced eosinophil and lymphocyte recruitment in rat airways in vivo, without affecting peripheral blood or bone marrow leukocytes.
Licensing Information
Sold with the permission of Astellas Pharma Inc.
Technical Data for YM 90709
| M. Wt | 359.43 |
| Formula | C22H21N3O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 163769-88-8 |
| PubChem ID | 1103147 |
| InChI Key | HIXSPVQXXDULHS-UHFFFAOYSA-N |
| Smiles | COC1=CC2=C(C=C1OC)C1=CC3=NC4=CC=CC=C4N=C3N1C(C)(C)C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for YM 90709
References for YM 90709
References are publications that support the biological activity of the product.
Morokata et al (2002) Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Int.Immunopharmacol. 2 1693 PMID: 12469943
Morokata et al (2004) Effect of a novel interleukin-5 receptor antagonist, YM-90709 (2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline), on antigen-induced airway inflammation in BN rats. Int.Immunopharmacol. 4 873 PMID: 15182727
Morokata et al (2005) Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into the airway of BDF1 mice. Immunol.Lett. 98 161 PMID: 15790522
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Keywords: YM 90709, YM 90709 supplier, Interleukin-5, receptor, inhibitors, inhibits, antagonists, IL, receptors, interleukins, cytokines, YM90709, IL-5, inhibitor, Cytokine, Receptors, 1675, Tocris Bioscience
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