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Submit ReviewYM 976
Description: PDE4 inhibitor
Chemical Name: 4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one
Purity: ≥98% (HPLC)
Biological Activity for YM 976
Orally active PDE4 inhibitor (IC50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration.
Technical Data for YM 976
| M. Wt | 313.79 |
| Formula | C17H16ClN3O |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 191219-80-4 |
| PubChem ID | 6604918 |
| InChI Key | MNHXYNNKDDXKNP-UHFFFAOYSA-N |
| Smiles | CCN1C(=O)N=C(C2=CC=CC(Cl)=C2)C2=C1N=C(CC)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for YM 976
References for YM 976
References are publications that support the biological activity of the product.
Aoki et al (2000) A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity. J.Pharmacol.Exp.Ther. 295 255 PMID: 10991987
Aoki et al (2001) Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. J.Pharmacol.Exp.Ther. 298 1142 PMID: 11504812
Moriuchi et al (2003) Relaxant effect of YM976, a novel phosphodiesterase 4 inhibitor, on bovine tracheal smooth muscle. Eur.J.Pharmacol. 470 57 PMID: 12787831
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Keywords: YM 976, YM 976 supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, YM976, 1821, Tocris Bioscience
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