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Submit ReviewYNT 185
Description: Potent and selective OX2 agonist
Chemical Name: 3'-[[[3-[[2-[[2-(Dimethylamino)benzoyl]amino]ethyl]amino]phenyl]amino]sulfonyl]-4'-methoxy-N,N-dimethyl-[1,1'-biphenyl]-3-carboxamide dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for YNT 185
YNT 185 is a potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.
Compound Libraries for YNT 185
YNT 185 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for YNT 185
| M. Wt | 688.66 |
| Formula | C33H37N5O5S.2HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1804978-82-2 |
| PubChem ID | 140307520 |
| InChI Key | AIORBDHFHVKRIY-UHFFFAOYSA-N |
| Smiles | COC1=C(S(=O)(NC2=CC(NCCNC(C3=C(N(C)C)C=CC=C3)=O)=CC=C2)=O)C=C(C4=CC(C(N(C)C)=O)=CC=C4)C=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for YNT 185
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 68.87 | 100 | |
| DMSO | 68.87 | 100 |
Preparing Stock Solutions for YNT 185
The following data is based on the product molecular weight 688.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.45 mL | 7.26 mL | 14.52 mL |
| 5 mM | 0.29 mL | 1.45 mL | 2.9 mL |
| 10 mM | 0.15 mL | 0.73 mL | 1.45 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.29 mL |
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Product Datasheets for YNT 185
References for YNT 185
References are publications that support the biological activity of the product.
Nagahara et al (2015) Design and synthesis of non-peptide, selective orexin receptor 2 agonists. J.Med.Chem. 58 7931 PMID: 26267383
Irukayama-Tomobe et al (2017) Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc.Natl.Acad.Sci.USA. 144 5731 PMID: 28507129
If you know of a relevant reference for YNT 185, please let us know.
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Keywords: YNT 185, YNT 185 supplier, YNT185, orexin, receptor, 2, agonists, agonism, OX1, selective, potent, sleep, wake, cycle, nacolepsy, cataplexy, OX2, Receptor, 6739, Tocris Bioscience
Citations for YNT 185
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.