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Submit ReviewZ 944
Description: CaV3.x blocker
Chemical Name: 4-[[(3-Chloro-5-fluorobenzoyl)amino)methyl]-N-(1,1-dimethylethyl)-1-piperidineacetamide
Purity: ≥98% (HPLC)
Biological Activity for Z 944
Z 944 is a selective T-type Ca2+ channel blocker (IC50 values are 50 to 160 nM for hCav3.1, hCav3.2 and hCav3.3). Exhibits 50 to 600 fold selectivity for Cav3.x channels over related ion channels (Cav1.2, hERG and Nav1.5). Has no effect on action potential properties in isolated heart Purkinje fibers and no adverse effects on ECG parameters in vivo. Exhibits anti-seizure effects in animal models.
Compound Libraries for Z 944
Z 944 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Z 944
| M. Wt | 383.89 |
| Formula | C19H27ClFN3O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1199236-64-0 |
| PubChem ID | 44540045 |
| InChI Key | JOCLITFYIMJMNK-UHFFFAOYSA-N |
| Smiles | CC(C)(NC(CN1CCC(CC1)CNC(C2=CC(Cl)=CC(F)=C2)=O)=O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Z 944
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.39 | 100 | |
| ethanol | 38.39 | 100 |
Preparing Stock Solutions for Z 944
The following data is based on the product molecular weight 383.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.6 mL | 13.02 mL | 26.05 mL |
| 5 mM | 0.52 mL | 2.6 mL | 5.21 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.6 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets for Z 944
References for Z 944
References are publications that support the biological activity of the product.
Tringham et al (2012) T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures. Sci.Transl.Med. 4 121 PMID: 22344687
Casillas-Espinosa et al (2015) Z944, a novel selective T-type calcium channel antagonist delays the progression of seizures in the amygdala kindling model. PLoS One. 10 e0130012 PMID: 26274319
If you know of a relevant reference for Z 944, please let us know.
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Keywords: Z 944, Z 944 supplier, Z944, T-type, calcium, channel, blockers, anti-epileptic, in, vivo, Cav3.1, Cav3.2, Cav3.3, Ca2+, blocks, Cav3.x, Channels, 6367, Tocris Bioscience
2 Citations for Z 944
Citations are publications that use Tocris products. Selected citations for Z 944 include:
Praveen et al (2020) A Thalamic Orphan Receptor Drives Variability in Short-Term Memory. Cell 183 522-536.e19 PMID: 32997977
Sean M et al (2021) Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon. Elife 10 PMID: 33399536
Do you know of a great paper that uses Z 944 from Tocris? Please let us know.
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