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Zaprinast

Cat. No. 0947 6 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: GPR35 agonist
Chemical Name: 2-(2-Propyloxyphenyl)-8-azapurin-6-one
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Zaprinast

Zaprinast is a phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Putative GPR35 agonist.

Compound Libraries for Zaprinast

Zaprinast is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Zaprinast

M. Wt 271.28
Formula C13H13N5O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 37762-06-4
PubChem ID 5722
InChI Key REZGGXNDEMKIQB-UHFFFAOYSA-N
Smiles CCCOC1=C(C=CC=C1)C1=NC2=C(NN=N2)C(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Zaprinast

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100

Preparing Stock Solutions for Zaprinast

The following data is based on the product molecular weight 271.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.69 mL 18.43 mL 36.86 mL
5 mM 0.74 mL 3.69 mL 7.37 mL
10 mM 0.37 mL 1.84 mL 3.69 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

Molarity Calculator

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Product Datasheets for Zaprinast

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Zaprinast

References are publications that support the biological activity of the product.

Lugnier (2006) Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. Pharmacol.Ther. 109 366 PMID: 16102838

Soderling et al (1998) Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J.Biol.Chem. 273 15553 PMID: 9624145

Taniguchi et al (2006) Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35. FEBS Lett. 580 5003 PMID: 16934253

Christensen and Torphy (1994) Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem. 29 185

If you know of a relevant reference for Zaprinast, please let us know.

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Keywords: Zaprinast, Zaprinast supplier, PDE5/6/9/11, inhibitors, inhibits, Phosphodiesterases, GPR35, 0947, Tocris Bioscience

6 Citations for Zaprinast

Citations are publications that use Tocris products. Selected citations for Zaprinast include:

MacKenzie et al (2014) The antiallergic mast cell stabilizers lodox. and bufrolin as the first high and equipotent agonists of human and rat GPR35. Mol Pharmacol 85 91 PMID: 24113750

Wyant et al (2022) Mitochondrial remodeling and ischemic protection by G protein–coupled receptor 35 agonists. Science 377 621 PMID: 35926043

Rojewska (2018) Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced mor. analgesia in a mouse neuropathic pain model. Pharmacol Rep 71 139 PMID: 30550994

Polcari et al (2013) Effect of the phosphodiesterase-5 inhibitor zaprinast on ischemia-reperfusion injury in rats. Proc Natl Acad Sci U S A 27 338 PMID: 22974473

Zerani et al (2004) Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea. J Endourol 183 279 PMID: 15531716

Robichaud et al (2002) Assessing the emetic potential of PDE4 inhibitors in rats. Br J Pharmacol 135 113 PMID: 11786486

Do you know of a great paper that uses Zaprinast from Tocris? Please let us know.

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