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Submit ReviewZD 7114 hydrochloride
Discontinued Product
0930 has been discontinued.
View all Adrenergic β<sub>3</sub> Receptors products.
Description: β3 agonist
Alternative Names: ICI D7114
Chemical Name: (S)-4-[2-Hydroxy-3-phenoxypropylaminoethoxy]-N-(2-methoxyethyl)phenoxyacetamide hydrochloride
Biological Activity for ZD 7114 hydrochloride
ZD 7114 hydrochloride is a β3-adrenoceptor agonist.
Active Metabolite also available.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data for ZD 7114 hydrochloride
| M. Wt | 454.95 |
| Formula | C22H30N2O6.HCl |
| Storage | Store at RT |
| CAS Number | 129689-28-7 |
| PubChem ID | 9890216 |
| InChI Key | KCAMZVQSGDBGGF-FERBBOLQSA-N |
| Smiles | O[C@H](COC2=CC=CC=C2)CNCCOC1=CC=C(OCC(NCCOC)=O)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ZD 7114 hydrochloride
Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service
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References for ZD 7114 hydrochloride
References are publications that support the biological activity of the product.
Growcott et al (1993) Evaluation of ICI D7114, a putative stimulant of brown adipocytes, on histamine-contracted guinea-pig ileum. Br.J.Pharmacol. 109 1212 PMID: 8104647
Savontaus et al (1998) Effects of ZD7114, a selective β3-adrenoceptor agonist, on neuroendocrine mechanisms controlling energy balance. Eur.J.Pharmacol. 347 265 PMID: 9653893
How (1993) β3-Adrenergic agonists. Drugs Future 18 529
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2 Citations for ZD 7114 hydrochloride
Citations are publications that use Tocris products. Selected citations for ZD 7114 hydrochloride include:
Baker et al (2011) Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J 25 4486 PMID: 21865315
Suárez et al (2014) Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech 7 129 PMID: 24159189
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.