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Submit ReviewZiprasidone hydrochloride
Description: 5-HT2A antagonist; also D2 antagonist; atypical antipsychotic
Alternative Names: CP 88059
Chemical Name: 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Ziprasidone hydrochloride
Atypical antipsychotic that displays combined serotonin and dopamine receptor antagonism. Displays high affinity at 5-HT2A receptors with a 5-HT2A/D2 affinity ratio greater than any other clinically available atypical antipsychotics (pKi values are 9.38, 8.88, 8.69, 8.47, 8.32, 8.14, 7.98, 7.49, 7.33 and 6.28 for 5-HT2A, 5-HT2C, 5-HT1D, 5-HT1A, D2, D3, α1, D4, H1 and D1 receptors respectively).
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for Ziprasidone hydrochloride
| M. Wt | 449.4 |
| Formula | C21H21ClN4OS.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 122883-93-6 |
| PubChem ID | 219099 |
| InChI Key | NZDBKBRIBJLNNT-UHFFFAOYSA-N |
| Smiles | O=C2CC1=CC(CCN3CCN(C4=NSC5=C4C=CC=C5)CC3)=C(Cl)C=C1N2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ziprasidone hydrochloride
References for Ziprasidone hydrochloride
References are publications that support the biological activity of the product.
Seeger et al (1995) Ziprasidone (CP-88,059): a new antipsychotic with combined DA and serotonin receptor antagonist activity. J.Pharmacol.Exp.Ther. 275 101 PMID: 7562537
Schmidt et al (2001) Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile. Eur.J.Pharmacol. 425 197 PMID: 11513838
Fell et al (2005) Investigation into the effects of the novel antipsychotic zipras. on weight gain and reproductive function in female rats. Behav.Brain Res. 160 338 PMID: 15863230
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Keywords: Ziprasidone hydrochloride, Ziprasidone hydrochloride supplier, 5-HT2A/D2, antagonists, atypical, antipsychotic, Serotonin, 5-HT2A, Receptors, Dopamine, dopaminergic, CP88059, Pfizer, 138982-67-9, CP, 88059, D2, 3085, Tocris Bioscience
3 Citations for Ziprasidone hydrochloride
Citations are publications that use Tocris products. Selected citations for Ziprasidone hydrochloride include:
Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480 PMID: 22817643
Canfrán-Duque et al (2015) Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro. Mediators Inflamm 10 e0141829 PMID: 26517556
Canfrán-Duque et al (2013) Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro. J Lipid Res 54 310 PMID: 23175778
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.