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Submit ReviewZK 756326
Description: Selective, non-peptide CCR8 agonist
Chemical Name: 2-[2-[4-[(3-phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for ZK 756326
ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50 values are 1.8 and 2.6 μM for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.
Technical Data for ZK 756326
| M. Wt | 429.38 |
| Formula | C21H28N2O3.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1780259-94-0 |
| PubChem ID | 56972201 |
| InChI Key | MPACCEKWFGWZHS-UHFFFAOYSA-N |
| Smiles | OCCOCCN(CC3)CCN3CC1=CC=CC(OC2=CC=CC=C2)=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ZK 756326
References for ZK 756326
References are publications that support the biological activity of the product.
Haskell et al (2006) Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8. Mol.Pharmacol. 69 309 PMID: 16221874
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Keywords: ZK 756326, ZK 756326 supplier, Selective, non-peptide, CCR8, agonists, CXCR, Chemokine, Receptors, ZK756326, CC, 2565, Tocris Bioscience
Citations for ZK 756326
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Currently there are no citations for ZK 756326.
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