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Submit ReviewZM 306416 hydrochloride
Description: Inhibitor of VEGF receptor tyrosine kinase
Chemical Name: 4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazoline hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for ZM 306416 hydrochloride
ZM 306416 hydrochloride is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. Inhibits activity of KDR and FLT VEGF receptors (IC50 values are 100 nM and 2 μM respectively) and displays > 3-fold selectivity over FGFR-1. Orally active in vivo.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data for ZM 306416 hydrochloride
| M. Wt | 370.21 |
| Formula | C16H13N3O2FCl.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 196603-47-1 |
| PubChem ID | 21701577 |
| InChI Key | SCUXIROMWPQVJO-UHFFFAOYSA-N |
| Smiles | Cl.COC1=C(OC)C=C2C(NC3=CC=C(Cl)C=C3F)=NC=NC2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ZM 306416 hydrochloride
References for ZM 306416 hydrochloride
References are publications that support the biological activity of the product.
Hennequin et al (1999) Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J.Med.Chem. 42 5369 PMID: 10639280
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Keywords: ZM 306416 hydrochloride, ZM 306416 hydrochloride supplier, inhibitors, inhibits, receptors, tyrosine, kinase, VEGFR, Vascular, Endothelial, Growth, Factor, Receptors, KDR, Flt, RTKs, ZM306416, hydrochloride, AstraZeneca, 2499, Tocris Bioscience
5 Citations for ZM 306416 hydrochloride
Citations are publications that use Tocris products. Selected citations for ZM 306416 hydrochloride include:
Lee et al (2014) FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling. Nat Commun 5 5583 PMID: 25428693
Zhang et al (2016) Inhibition of vascular endothelial growth factor signaling facilitates liver repair from acute ethanol-induced injury in zebrafish. Dis Model Mech 9 1383 PMID: 27562099
Crouch et al (2015) Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage. J Biomol Screen 35 4528 PMID: 25788671
Yuan et al (2015) Endothelial cells enhance the migration of bovine meniscus cells. Arthritis Rheumatol 67 182 PMID: 25307081
Marino et al (2018) Regulation of breast cancer induced bone disease by cancer-specific IKKβ. Oncotarget 9 16134 PMID: 29662632
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Literature in this Area
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Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
Pathways for ZM 306416 hydrochloride
