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ZNL 02-096

Cat. No. 7240 Submit a Review Datasheet / COA / SDS
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Description: Potent and selective Wee1 Degrader (PROTAC®)
Chemical Name: 4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ZNL 02-096

ZNL 02-096 is a potent and selective Wee1 Degrader (PROTAC®) that comprises the Wee1 inhibitor AZD 1775 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat. No. 6302). ZNL 02-096 selectively degrades Wee1 at submicromolar concentrations, while sparing PLK1, an AZD 1775 secondary target. In MOLT-4 cells in vitro, ZNL 02-096 induces degradation of Wee1, accumulation of DNA damage, arrest of the cell cycle in the G2/M phase and apoptosis. The compound shows antiproliferative effects in a panel of 300 cancer cell lines.

Wee1 antibody validated for Western Blot also available: Catalog # NBP1-33506.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Technical Data for ZNL 02-096

M. Wt 799.89
Formula C42H45N11O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2414418-49-6
PubChem ID 153555373
InChI Key LZUDSNUROXNVPH-UHFFFAOYSA-N
Smiles CC(O)(C1=NC(N2N(C(C3=CN=C(N=C23)NC4=CC=C(N5CCN(CC5)CCCNC6=C7C(N(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)C=C4)=O)CC=C)=CC=C1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ZNL 02-096

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.99 50

Preparing Stock Solutions for ZNL 02-096

The following data is based on the product molecular weight 799.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.5 mL 12.5 mL 25 mL
2.5 mM 0.5 mL 2.5 mL 5 mL
5 mM 0.25 mL 1.25 mL 2.5 mL
25 mM 0.05 mL 0.25 mL 0.5 mL

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References for ZNL 02-096

References are publications that support the biological activity of the product.

Li et al (2020) Development and characterization of a Wee1 kinase degrader. Cell Chem.Biol. 27 57 PMID: 31735695

If you know of a relevant reference for ZNL 02-096, please let us know.

View Related Products by Target

Keywords: ZNL 02-096, ZNL 02-096 supplier, ZNL02-096, Wee1, Degrader, PROTAC, PROTACs, AZD, 1775, selective, TPD, targeted, protein, degradation, Checkpoint, Kinases, Control, Kinase, Degraders, 7240, Tocris Bioscience

Citations for ZNL 02-096

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia