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Zoledronic Acid

Cat. No. 6111 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent farnesyl diphosphate (FPP) synthase inhibitor
Alternative Names: Zometa
Chemical Name: [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Zoledronic Acid

Zoledronic Acid is a potent bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM). Inhibits osteoclast-mediated bone resorption. Also inhibits Ras signaling and tumor growth, and induces apoptosis in pancreatic cancer cells. Reverses epithelial-mesenchymal transition and inhibits breast cancer cell renewal via inactivation of NF-κB.

Technical Data for Zoledronic Acid

M. Wt 272.09
Formula C5H10N2O7P2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 118072-93-8
PubChem ID 68740
InChI Key XRASPMIURGNCCH-UHFFFAOYSA-N
Smiles OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Zoledronic Acid

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 13.6 50
water 0.68 2.5

Preparing Stock Solutions for Zoledronic Acid

The following data is based on the product molecular weight 272.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.35 mL 36.75 mL 73.51 mL
2.5 mM 1.47 mL 7.35 mL 14.7 mL
5 mM 0.74 mL 3.68 mL 7.35 mL
25 mM 0.15 mL 0.74 mL 1.47 mL

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Product Datasheets for Zoledronic Acid

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Zoledronic Acid

References are publications that support the biological activity of the product.

Schech et al (2013) Zoledronic acid reverses the epithelial-mesenchymal transition and inhibits self-renewal of breast cancer cells through inactivation of NF-κB. Mol.Cancer Ther. 12 1356 PMID: 23619300

Tassone et al (2003) Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. Br.J.Cancer 88 1971 PMID: 12799645

Dunford et al (2001) Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J.Pharmacol.Exp.Ther. 296 235 PMID: 11160603

If you know of a relevant reference for Zoledronic Acid, please let us know.

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Keywords: Zoledronic Acid, Zoledronic Acid supplier, bisphosphonate, NF-KB, NF-kappaB, NF-κB, signaling, inhibitors, inhibits, potent, FPP, synthase, farnesyl, diphosphate, Ras, Zometa, Other, Synthases/Synthetases, NF-kB/IkB, Cancer, Stem, Cells, GTPases, 6111, Tocris Bioscience

1 Citation for Zoledronic Acid

Citations are publications that use Tocris products. Selected citations for Zoledronic Acid include:

E et al (2020) GLP-2 administration in ovariectomized mice enhances collagen maturity but did not improve bone strength. Bone Rep 12 100251 PMID: 32071954

Do you know of a great paper that uses Zoledronic Acid from Tocris? Please let us know.

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