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Submit ReviewZoniporide dihydrochloride
Description: Selective NHE1 inhibitor
Alternative Names: CP 597396
Chemical Name: [1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Zoniporide dihydrochloride
Zoniporide dihydrochloride is a sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (Ki values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent 22Na+ uptake in vitro (IC50 = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC50 = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc
Compound Libraries for Zoniporide dihydrochloride
Zoniporide dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Zoniporide dihydrochloride
| M. Wt | 393.27 |
| Formula | C17H16N6O.2HCl |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 241799-10-0 |
| PubChem ID | 22267855 |
| InChI Key | ARZNPJAGKWHEHT-UHFFFAOYSA-N |
| Smiles | O=C(/N=C(N)/N)C(C=N3)=C(C4CC4)N3C1=C2C(N=CC=C2)=CC=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Zoniporide dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.93 | 10 | |
| DMSO | 39.33 | 100 |
Preparing Stock Solutions for Zoniporide dihydrochloride
The following data is based on the product molecular weight 393.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.54 mL | 12.71 mL | 25.43 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.09 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.54 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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Product Datasheets for Zoniporide dihydrochloride
References for Zoniporide dihydrochloride
References are publications that support the biological activity of the product.
Knight et al (2001) A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. J.Pharmacol.Exp.Ther. 297 254 PMID: 11259552
Marala et al (2002) Zoniporide: a potent and highly selective inhibitor of human Na+/H+ exchanger-1. Eur.J.Pharmacol. 451 37 PMID: 12223226
Clements-Jewery et al (2004) Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of Na+/H+ exchanger isoform-1, in an experimental model of cardiopulmonary bypass. Br.J.Pharmacol. 142 57 PMID: 15037516
If you know of a relevant reference for Zoniporide dihydrochloride, please let us know.
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Keywords: Zoniporide dihydrochloride, Zoniporide dihydrochloride supplier, Selective, NHE-1, inhibitors, inhibits, Ion, Pumps, Transporters, Sodium-hydrogen, exchanger, isoform-1, CP597396, CP, 597396, Na+/H+, Exchanger, 2727, Tocris Bioscience
2 Citations for Zoniporide dihydrochloride
Citations are publications that use Tocris products. Selected citations for Zoniporide dihydrochloride include:
Féraille et al (2014) NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity. PLoS One 9 e87239 PMID: 24466344
Goldman et al (2011) The Na+/H+ exchanger controls deoxycholic acid-induced apoptosis by a H+-activated, Na+-dependent ionic shift in esophageal cells. PLoS One 6 e23835 PMID: 21887327
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