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Submit ReviewLidocaine
Description: Na+ channel blocker
Chemical Name: 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
Purity: ≥99% (HPLC)
Biological Activity for Lidocaine
Lidocaine is an anasthetic and class Ib antiarrhythmic agent. Blocks voltage-gated sodium channels in the inactivated state.
Technical Data for Lidocaine
| M. Wt | 234.34 |
| Formula | C14H22N2O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 137-58-6 |
| PubChem ID | 3676 |
| InChI Key | NNJVILVZKWQKPM-UHFFFAOYSA-N |
| Smiles | O=C(CN(CC)CC)NC1=C(C)C=CC=C1C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Lidocaine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 23.43 | 100 | |
| DMSO | 23.43 | 100 |
Preparing Stock Solutions for Lidocaine
The following data is based on the product molecular weight 234.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.27 mL | 21.34 mL | 42.67 mL |
| 5 mM | 0.85 mL | 4.27 mL | 8.53 mL |
| 10 mM | 0.43 mL | 2.13 mL | 4.27 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.85 mL |
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Product Datasheets for Lidocaine
References for Lidocaine
References are publications that support the biological activity of the product.
Sarraf et al (2003) Tedisamil and lidocaine enhance each other's antiarrhythmic activity against ischaemia-induced arrhythmias in rats. Br.J.Pharmacol. 139 1389 PMID: 12922925
If you know of a relevant reference for Lidocaine, please let us know.
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Keywords: Lidocaine, Lidocaine supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, 3057, Tocris Bioscience
2 Citations for Lidocaine
Citations are publications that use Tocris products. Selected citations for Lidocaine include:
Miguel Angel Garcia-Bereguiain et al (2016) Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo The Journal of Neuroscience 6 7268 PMID: 27383600
Hernández-Cascales (2017) Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium. PeerJ 5 e3113 PMID: 28382232
Do you know of a great paper that uses Lidocaine from Tocris? Please let us know.
Reviews for Lidocaine
Average Rating: 5 (Based on 1 Review.)
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Lidocaine in prelimbic medial prefrontal cortex blocks cue-induced reinstatement of MDMA seeking.
By
Kevin Ball on 01/25/2019
Assay Type: In Vivo
Species: Rat
Bilateral microinjections of lidocaine (100 micrograms/0.5 microliter/side) into prelimbic, but not infralimbic, medial prefrontal cortex blocked cue-induced reinstatement of MDMA (ecstasy)-seeking behavior compared with saline microinjections into the same region. Lidocaine microinjections into either region did not, however, have an effect on food-maintained responding, ruling out a nonspecific disruption of motor performance.
