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Submit ReviewCarbamazepine
Description: Inhibitor of neuronal NaV channels; anticonvulsant
Alternative Names: CBZ
Chemical Name: 5H-Dibenz[b,f]azepine-5-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for Carbamazepine
Carbamazepine is an inhibitor of neuronal voltage-gated Na+ channels. Exhibits anticonvulsant activity. Potentiates GABA-induced Cl- currents in HEK 293 cells expressing the GABAA receptor α1β2γ2 subtype combination. Can induce autophagy by inhibiting inositol synthesis. Also delays disease onset and prolongs survival in a mouse amyotrophic lateral sclerosis (ALS) model, as well as reducing motor neuron loss and altered muscle morphology.
Compound Libraries for Carbamazepine
Carbamazepine is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Carbamazepine
| M. Wt | 236.27 |
| Formula | C15H12N2O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 298-46-4 |
| PubChem ID | 2554 |
| InChI Key | FFGPTBGBLSHEPO-UHFFFAOYSA-N |
| Smiles | NC(N1C3=C(C=CC=C3)C=CC2=C1C=CC=C2)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Carbamazepine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.63 | 100 | |
| ethanol | 5.91 | 25 |
Preparing Stock Solutions for Carbamazepine
The following data is based on the product molecular weight 236.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.23 mL | 21.16 mL | 42.32 mL |
| 5 mM | 0.85 mL | 4.23 mL | 8.46 mL |
| 10 mM | 0.42 mL | 2.12 mL | 4.23 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.85 mL |
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Product Datasheets for Carbamazepine
References for Carbamazepine
References are publications that support the biological activity of the product.
Granger et al (1995) Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamaz. and phen. Mol.Pharmacol. 47 1189 PMID: 7603459
Afanas'ev et al (1999) Lamotrigine and carbamaz. affect differently the release of D-[3H] aspartate from mouse cerebral cortex slices: involvement of NO. Neurochem.Res. 24 1153 PMID: 10485587
Lipkind and Fozzard (2010) Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore. Mol.Pharmacol. 78 631 PMID: 20643904
Sarkar et al (2009) Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ. 16 46 PMID: 18636076
Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 16 487 PMID: 28529316
Zhang et al (2018) Repurposing carbamaz. for the treatment of amyotrophic lateral sclerosis in SOD1-G93A mouse model. CNS Neurosci.Ther. 24 1163 PMID: 29656576
If you know of a relevant reference for Carbamazepine, please let us know.
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Keywords: Carbamazepine, Carbamazepine supplier, sodium, Na+, channels, GABAA, ligands, inhibits, inhibitors, anticonvulsants, CBZ, Voltage-gated, Sodium, Channels, Autophagy, 4098, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Carbamazepine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
4 Citations for Carbamazepine
Citations are publications that use Tocris products. Selected citations for Carbamazepine include:
Eero et al (2022) Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro. Front Pharmacol 12 755600 PMID: 35126106
Hui et al (2022) Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate. Mol Cell 82 2401-2414.e9 PMID: 35597236
Jing et al (2021) Cerebellar spreading depolarization mediates paroxysmal movement disorder. Cell Rep 36 109743 PMID: 34551285
Gábor et al (2017) Mechanisms for Selective Single-Cell Reactivation during Offline Sharp-Wave Ripples and Their Distortion by Fast Ripples. Neuron 94 1234-1247.e7 PMID: 28641116
Do you know of a great paper that uses Carbamazepine from Tocris? Please let us know.
Reviews for Carbamazepine
Average Rating: 5 (Based on 1 Review.)
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Carbamazepine's effect on serotonin systems observed.
By
Anonymous on 01/16/2020
Species: Human
Carbamazepine's effect on serotonin systems observed and an attempt to explain how it exert it's antiseizure effects was made.
There is evidence that it is a serotonin releasing agent and possibly even a serotonin reuptake inhibitor
