H⁺,K⁺-ATPase

H⁺, K⁺-ATPases are gastric proton pumps that function to maintain an acidic environment within the stomach. They are found in parietal cells of the gastric mucosa and transport H⁺ and K⁺ ions against their concentration gradients using energy derived from the hydrolysis of ATP.

H⁺, K⁺-ATPases are P-type ATPases that exist as heterodimers, consisting of an α- and a β-subunit. The α-subunit, coded by the ATP4A gene on human chromosome 19q13.1, contains the catalytic site and mediates ion transport. The β-subunit, coded by the ATP4B gene on human chromosome 13q34, acts to stabilize the α-subunit and is essential for enzyme function.

Overactivity of H⁺, K⁺-ATPases causes inflammation of the gastric epithelium and these transporters are the pharmacological target in the treatment of peptic ulcer disease, dyspepsia and gastro-esophageal reflux disease (GORD).

External sources of pharmacological information for H⁺,K⁺-ATPase :

• BJP Guide

H⁺,K⁺-ATPase Gene Data