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说明： Epithelial KCa channel activator
化学名： 1-Ethyl-2-benzimidazolinone
纯度： ≥99% (HPLC)
生物活性 for 1-EBIO
1-EBIO is an activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.
化合物库 for 1-EBIO
1-EBIO is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for 1-EBIO
| 分子量 | 162.19 |
| 公式 | C9H10N2O |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 10045-45-1 |
| PubChem ID | 82320 |
| InChI Key | CXUCKELNYMZTRT-UHFFFAOYSA-N |
| Smiles | CCN1C(=O)NC2=C1C=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 1-EBIO
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 16.22 | 100 | |
| DMSO | 16.22 | 100 |
制备储备液 for 1-EBIO
以下数据基于产品分子量 162.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.17 mL | 30.83 mL | 61.66 mL |
| 5 mM | 1.23 mL | 6.17 mL | 12.33 mL |
| 10 mM | 0.62 mL | 3.08 mL | 6.17 mL |
| 50 mM | 0.12 mL | 0.62 mL | 1.23 mL |
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产品说明书 for 1-EBIO
参考文献 for 1-EBIO
参考文献是支持产品生物活性的出版物。
Ayotunde and Adeagbo (1999) 1-Ethyl-2-benzimidazolinone stimulates endothelial KCa channels and nitric oxide formation in rat mesenteric vessels. Eur.J.Pharmacol. 379 151 PMID: 10497901
Devor et al (1996) Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca2+ - dependent K+ channel. Am.J.Physiol. 271 L775 PMID: 8944721
Kusama et al (2005) Reduced hyperpolarisation in endothelial cells of rabbit aortic value following chronic nitroglycerine administration. Br.J.Pharmacol. 146 487 PMID: 16056232
Kleger et al (2010) Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells. Circulation. 122 1823 PMID: 20956206
If you know of a relevant reference for 1-EBIO, please let us know.
按标靶查看相关产品
关键词: 1-EBIO, 1-EBIO supplier, Activator, epithelial, Kca, channels, Potassium, Channels, ca2+-activated, ca2+-dependent, K+, Ca2+-Activated, Cardiomyocyte, Stem, Cells, ESCs, and, iPSC, 1041, Tocris Bioscience
16 篇 1-EBIO 的引用文献
引用文献是使用了 Tocris 产品的出版物。 1-EBIO 的部分引用包括：
Gamble-George et al (2016) Cyclooxygenase-2 inhibition reduces stress-induced affective pathology. Elife 5 PMID: 27162170
Rau et al (2015) Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress. BMC Dermatol 35 9730 PMID: 26134655
Cruse et al (2011) Functional KCa3.1 K+ channels are required for human fibrocyte migration. J Allergy Clin Immunol 128 1303 PMID: 21872912
Wells et al (2016) Thalamic reticular impairment underlies attention deficit in Ptchd1(Y/-) mice. Nature 532 58 PMID: 27007844
Lai et al (2011) PRL-3 promotes the proliferation of LoVo cells via the upregulation of KCNN4 channels. Oncol Rep 26 909 PMID: 21725609
Park et al (2011) Globotriaosylceramide leads to K(Ca)3.1 channel dysfunction: a new insight into endothelial dysfunction in Fabry disease. Cardiovasc Res 89 290 PMID: 20971723
Haddock et al (2011) Diet-induced obesity impairs endothelium-derived hyperpolarization via altered potassium channel signaling mechanisms. PLoS One 6 e16423 PMID: 21283658
Manaves et al (2004) Calcium and Vitamin D increase mRNA levels for the growth control hIK1 channel in human epidermal keratinocytes but functional channels are not observed. Korean J Physiol Pharmacol 4 7 PMID: 15200683
Banderali et al (2004) New insights on the voltage dependence of the KCa3.1 channel block by internal TBA. J Gen Physiol 124 333 PMID: 15452196
Kusama et al (2005) Reduced hyperpolarization in endothelial cells of rabbit aortic valve following chronic nitroglycerine administration. Br J Pharmacol 146 487 PMID: 16056232
Cuppoletti et al (2014) Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents. Am J Physiol Cell Physiol 307 C479 PMID: 25009109
Bushart et al (2018) Targeting potassium channels to treat cerebellar ataxia. Ann Clin Transl Neurol 5 297 PMID: 29560375
Duffy et al (2007) Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor. Proc Natl Acad Sci U S A 37 1653 PMID: 17474152
Choi et al (2013) Contradictory Effects of Superoxide and Hydrogen Peroxide on KCa3.1 in Human Endothelial Cells. Eur J Immunol 17 181 PMID: 23776393
Benton et al (2013) Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol 109 2528 PMID: 23446695
Cuppoletti et al (2013) Methadone but not mor. inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents. Cell Biochem Biophys 66 53 PMID: 22918821
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1-EBIO 的评论
平均评分: 5 (Based on 1 Review.)
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Study on BK channel activity.
By
Eleanor Baxter on 10/23/2018
分析类型： In Vitro
种属： Human
It activates Ca2+ activated K+ channels on epithelium. Our University lab uses it to study Big Conductance Channel channel opening.
