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Submit Review1-Oleoyl lysophosphatidic acid sodium salt
说明： Endogenous agonist of LPA1 and LPA2
化学名： 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoric acid sodium salt
生物活性
1-Oleoyl lysophosphatidic acid sodium salt is an endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. 1-Oleoyl lysophosphatidic acid sodium salt inhibits differentiation of neural stem cells (NSCs) into neurons.
Note: This product is typically prepared in PBS, pH 7.2, at a concentration of up to approximately 4 mg/mL.
技术数据
| 分子量 | 458.5 |
| 公式 | C21H40NaO7P |
| 储存 | Store at -20°C |
| CAS Number | 325465-93-8 |
| PubChem ID | 44159357 |
| InChI Key | XGRLSUFHELJJAB-JGSYTFBMSA-M |
| Smiles | [Na+].CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)COP(O)([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书
参考文献
参考文献是支持产品生物活性的出版物。
van Corven et al (1992) Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Biochem.J. 281 163 PMID: 1731751
Dottori et al (2008) Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells. Stem Cells 26 1146 PMID: 18308941
Lapierre et al (2010) Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. J.Biol.Chem. 285 25792 PMID: 20551326
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关键词: 1-Oleoyl lysophosphatidic acid sodium salt, 1-Oleoyl lysophosphatidic acid sodium salt supplier, lysophosphatidic, acid, LPA, lysophospholipid, receptors, LPL-R, agonists, Lysophosphatidic, Acid, Receptors, Neural, Stem, Cells, 3854, Tocris Bioscience
10 篇 1-Oleoyl lysophosphatidic acid sodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 1-Oleoyl lysophosphatidic acid sodium salt 的部分引用包括：
Maria et al (2023) Generating human blastoids modeling blastocyst-stage embryos and implantation. Nat Protoc 18 1584-1620 PMID: 36792779
Ruprecht et al (2015) Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. J Clin Invest 160 673 PMID: 25679761
Fernando Rodríguez et al (2021) Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis. Mol Neurobiol 58 470-482 PMID: 32974731
JoAnn et al (2021) α-Arrestin ARRDC3 tumor suppressor function is linked to GPCR-induced TAZ activation and breast cancer metastasis. J Cell Sci 134 PMID: 33722977
Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888
Guang et al (2022) Human embryos in a dish - modeling early embryonic development with pluripotent stem cells. Cell Regen 11 4 PMID: 35029775
Maria et al (2022) Human blastoids model blastocyst development and implantation. Nature 601 600-605 PMID: 34856602
Natarajan V et al (2022) Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction. Nat Cell Biol 24 858-871 PMID: 35697783
Jop et al (2022) A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression. Development 149 PMID: 35993866
Janet et al (2022) Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells. Cell Stem Cell 29 1346-1365.e10 PMID: 36055191
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LPA induces COX-2 expression in osteosacroma cells.
By
Anonymous on 12/13/2018
分析类型： In Vitro
种属： Human
细胞系/组织： Osteosarcoma
MG-63 cells were pre-incubated with indicated inhibitors for 30 min followed by treatment with 10 µM LPA for 3 h to follow COX-2 expression using Western blot. All inhibitors prevented COX-2 induction by LPA.
Works to deplete stem cell pool.
By
Anonymous on 11/18/2018
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： mammary gland
Primary mouse mammary glands were digested, incubated with LPA or control at 5uM and then analyzed using CD24/CD29 to identify effects on the stem cell pool. A 50% reduction in the stem cell pool (p4) was identified after LPA treatment.
LPA induces COX-2 expression in MG-63 cells.
By
Christopher Trummer on 10/23/2018
分析类型： In Vitro
种属： Human
细胞系/组织： Osteosarcoma
MG-63 cells were treated with 10 µM LPA (0-48 h) to follow COX-2 expression using Western blot. LPA induced COX-2 expression in a time-dependent manner in osteosarcoma cells.
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