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Submit Review17-DMAG hydrochloride
说明： Water-soluble Hsp90 inhibitor
别名： NSC 707545
化学名： 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin hydrochloride
纯度： ≥99% (HPLC)
生物活性 for 17-DMAG hydrochloride
17-DMAG hydrochloride is a water-soluble analog of 17-AAG (Cat. No. 1515) and geldanamycin (Cat. No. 1368). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).
许可信息
Sold with the permission of the NIH, US Patent 6,890,917
技术数据 for 17-DMAG hydrochloride
| 分子量 | 653.21 |
| 公式 | C32H48N4O8.HCl |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 467214-21-7 |
| PubChem ID | 9852573 |
| InChI Key | DFSYBWLNYPEFJK-IHLRWNDRSA-N |
| Smiles | O=C1C(NCCN(C)C)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for 17-DMAG hydrochloride
参考文献 for 17-DMAG hydrochloride
参考文献是支持产品生物活性的出版物。
Egorin et al (2002) Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and fischer 344 rats. Cancer Chemother.Pharmacol. 49 7 PMID: 11855755
Smith et al (2005) Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models. Cancer Chemother.Pharmacol. 56 126 PMID: 15841378
Dote et al (2006) Inhibition of Hsp90 compromises the DNA damage response to radiation. Cancer Res. 66 9211 PMID: 16982765
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关键词: 17-DMAG hydrochloride, 17-DMAG hydrochloride supplier, Water-soluble, Hsp90, inhibitors, inhibits, Heat, Shock, Protein, 90, NSC707545, antibiotics, NSC, 707545, Antibiotics, 2610, Tocris Bioscience
1 篇 17-DMAG hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 17-DMAG hydrochloride 的部分引用包括：
Young et al (2015) A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Mol Med 11 113 PMID: 25700737
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