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2-Chloro-N6-cyclopentyladenosine

Cat. No. 1705 11 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective A1 agonist
别名： CCPA
化学名： 2-Chloro-N-cyclopentyladenosine
纯度： ≥98% (HPLC)
说明书
引用文献 (11)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 2-Chloro-N6-cyclopentyladenosine

2-Chloro-N6-cyclopentyladenosine is a potent and selective adenosine A1 receptor agonist (Ki values are 0.8, 2300 and 42 nM for human A1, A2A and A3 receptors respectively; EC50 = 18800 nM for hA2B). Centrally active following systemic administration in vivo.

化合物库 for 2-Chloro-N6-cyclopentyladenosine

2-Chloro-N6-cyclopentyladenosine is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for 2-Chloro-N6-cyclopentyladenosine

分子量 369.81
公式 C15H20ClN5O4
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 37739-05-2
PubChem ID 123807
InChI Key XSMYYYQVWPZWIZ-IDTAVKCVSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N(C=N4)C2=C4C(NC3CCCC3)=NC(Cl)=N2)[C@@H]1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 2-Chloro-N6-cyclopentyladenosine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.98 100
ethanol 36.98 100

制备储备液 for 2-Chloro-N6-cyclopentyladenosine

以下数据基于产品分子量 369.81。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.7 mL 13.52 mL 27.04 mL
5 mM 0.54 mL 2.7 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.7 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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产品说明书 for 2-Chloro-N6-cyclopentyladenosine

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for 2-Chloro-N6-cyclopentyladenosine

参考文献是支持产品生物活性的出版物。

Concas et al (1993) Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain. J.Pharmacol.Exp.Ther. 267 844 PMID: 8246158

Klotz (2000) Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 362 382 PMID: 11111832

Lohse et al (1988) 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors. Naunyn Schmiedebergs Arch.Pharmacol. 337 687 PMID: 3216901

Monopoli et al (1994) Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine. Arzneimittelforschung 44 1305 PMID: 7848348

If you know of a relevant reference for 2-Chloro-N6-cyclopentyladenosine, please let us know.

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关键词: 2-Chloro-N6-cyclopentyladenosine, 2-Chloro-N6-cyclopentyladenosine supplier, Potent, selective, A1, agonists, Receptors, adenosines, CCPA, Adenosine, 1705, Tocris Bioscience

11 篇 2-Chloro-N6-cyclopentyladenosine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 2-Chloro-N6-cyclopentyladenosine 的部分引用包括：

Keene et al (2010) Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor. Biochem Pharmacol 80 188 PMID: 20346920

Crawford et al (2012) Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro. Cell Calcium 32 13100 PMID: 22993427

Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Neuroscience 32 14489 PMID: 23077035

Long et al (2010) Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine. J Neurosci 335 781 PMID: 20855445

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