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Submit Review2-Chloro-N6-cyclopentyladenosine
说明： Potent and selective A1 agonist
别名： CCPA
化学名： 2-Chloro-N-cyclopentyladenosine
纯度： ≥98% (HPLC)
生物活性 for 2-Chloro-N6-cyclopentyladenosine
2-Chloro-N6-cyclopentyladenosine is a potent and selective adenosine A1 receptor agonist (Ki values are 0.8, 2300 and 42 nM for human A1, A2A and A3 receptors respectively; EC50 = 18800 nM for hA2B). Centrally active following systemic administration in vivo.
化合物库 for 2-Chloro-N6-cyclopentyladenosine
2-Chloro-N6-cyclopentyladenosine is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for 2-Chloro-N6-cyclopentyladenosine
| 分子量 | 369.81 |
| 公式 | C15H20ClN5O4 |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 37739-05-2 |
| PubChem ID | 123807 |
| InChI Key | XSMYYYQVWPZWIZ-IDTAVKCVSA-N |
| Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N(C=N4)C2=C4C(NC3CCCC3)=NC(Cl)=N2)[C@@H]1O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 2-Chloro-N6-cyclopentyladenosine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 36.98 | 100 | |
| ethanol | 36.98 | 100 |
制备储备液 for 2-Chloro-N6-cyclopentyladenosine
以下数据基于产品分子量 369.81。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.7 mL | 13.52 mL | 27.04 mL |
| 5 mM | 0.54 mL | 2.7 mL | 5.41 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.7 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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产品说明书 for 2-Chloro-N6-cyclopentyladenosine
参考文献 for 2-Chloro-N6-cyclopentyladenosine
参考文献是支持产品生物活性的出版物。
Concas et al (1993) Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain. J.Pharmacol.Exp.Ther. 267 844 PMID: 8246158
Klotz (2000) Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 362 382 PMID: 11111832
Lohse et al (1988) 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors. Naunyn Schmiedebergs Arch.Pharmacol. 337 687 PMID: 3216901
Monopoli et al (1994) Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine. Arzneimittelforschung 44 1305 PMID: 7848348
If you know of a relevant reference for 2-Chloro-N6-cyclopentyladenosine, please let us know.
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关键词: 2-Chloro-N6-cyclopentyladenosine, 2-Chloro-N6-cyclopentyladenosine supplier, Potent, selective, A1, agonists, Receptors, adenosines, CCPA, Adenosine, 1705, Tocris Bioscience
11 篇 2-Chloro-N6-cyclopentyladenosine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 2-Chloro-N6-cyclopentyladenosine 的部分引用包括：
Ru et al (2011) Adenosine-induced activation of esophageal nociceptors. Am J Physiol Gastrointest Liver Physiol 300 G485 PMID: 21148396
Carman et al (2011) Adenosine receptor signaling modulates permeability of the blood-brain barrier. J Neurosci 31 13272 PMID: 21917810
Park et al (2012) Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia. Kidney Int 82 878 PMID: 22695326
Fabera et al (2019) Adenosine A1 Receptor Agonist 2-chloro-N6-cyclopentyladenosine and Hippocampal Excitability During Brain Development in Rats. Front Pharmacol 10 656 PMID: 31258477
Keene et al (2010) Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor. Biochem Pharmacol 80 188 PMID: 20346920
Long et al (2010) Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine. J Neurosci 335 781 PMID: 20855445
Crawford et al (2012) Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro. Cell Calcium 32 13100 PMID: 22993427
Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Neuroscience 32 14489 PMID: 23077035
Wu et al (2013) Opiate-induced changes in brain adenosine levels and narcotic drug responses. J Neurosci 228 235 PMID: 23098802
Goldman et al (2013) Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts. BMC Pharmacol Toxicol 53 297 PMID: 23462235
Loram et al (2013) Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling. Brain Behav Immun 33 112 PMID: 23811314
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