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Submit Review2-Hydroxysaclofen
说明： Selective GABAB antagonist; more potent than Saclofen (Cat. No. 0246)
化学名： (RS)-3-Amino-2-(4-chlorophenyl)-2-hydroxypropyl-sulfonic acid
生物活性 for 2-Hydroxysaclofen
2-Hydroxysaclofen is a selective antagonist at GABAB receptors.
技术数据 for 2-Hydroxysaclofen
| 分子量 | 265.71 |
| 公式 | C9H12ClNO4S |
| 储存 | Store at RT |
| CAS Number | 117354-64-0 |
| PubChem ID | 1564 |
| InChI Key | WBSMZVIMANOCNX-UHFFFAOYSA-N |
| Smiles | NCC(O)(CS(O)(=O)=O)C1=CC=C(Cl)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 2-Hydroxysaclofen
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 5 | ||
| 1eq. NaOH | 100 |
制备储备液 for 2-Hydroxysaclofen
以下数据基于产品分子量 265.71。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.76 mL | 18.82 mL | 37.64 mL |
| 5 mM | 0.75 mL | 3.76 mL | 7.53 mL |
| 10 mM | 0.38 mL | 1.88 mL | 3.76 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
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产品说明书 for 2-Hydroxysaclofen
参考文献 for 2-Hydroxysaclofen
参考文献是支持产品生物活性的出版物。
Curtis et al (1988) Baclofen antagonism by 2-hydroxysaclofen in the cat spinal cord. Neurosci.Lett. 92 97 PMID: 2847093
Kerr et al (1988) 2-Hydroxysaclofen: an improved antagonist at central and peripheral GABAB receptors. Neurosci.Lett. 92 92 PMID: 2847092
If you know of a relevant reference for 2-Hydroxysaclofen, please let us know.
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关键词: 2-Hydroxysaclofen, 2-Hydroxysaclofen supplier, Selective, GABAB, antagonists, Receptors, 0245, Tocris Bioscience
2 篇 2-Hydroxysaclofen 的引用文献
引用文献是使用了 Tocris 产品的出版物。 2-Hydroxysaclofen 的部分引用包括：
Piet et al (2004) Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. Nature 101 2151 PMID: 14766975
Piqueras and Martínez (2004) Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol 142 1038 PMID: 15210585
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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