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2'-MeCCPA

Cat. No. 2281 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Highly selective and potent A1 receptor agonist
化学名： 2-Chloro-N-cyclopentyl-2'-methyladenosine
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 2'-MeCCPA

2'-MeCCPA is a potent and highly selective agonist at A1 adenosine receptors (Ki values are 3.3, 9580, 37600 and 1150 nM for human recombinant A1, A2A, A2B and A3 receptors respectively). Acts as a full agonist; inhibits forskolin-stimulated adenylyl cyclase activity in rat cortical membranes with an IC50 value of 13.1 nM.

化合物库 for 2'-MeCCPA

2'-MeCCPA is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for 2'-MeCCPA

分子量 383.83
公式 C16H22ClN5O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 205171-12-6
PubChem ID 10475082
InChI Key MMPAUXMIDJWGFO-ROMFRFKVSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC3=C2N=C(Cl)N=C3NC4CCCC4)[C@@](C)1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 2'-MeCCPA

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 9.6 25

制备储备液 for 2'-MeCCPA

以下数据基于产品分子量 383.83。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.25 mM 10.42 mL 52.11 mL 104.21 mL
1.25 mM 2.08 mL 10.42 mL 20.84 mL
2.5 mM 1.04 mL 5.21 mL 10.42 mL
12.5 mM 0.21 mL 1.04 mL 2.08 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for 2'-MeCCPA

参考文献是支持产品生物活性的出版物。

Franchetti et al (1998) 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. J.Med.Chem. 41 1708 PMID: 9572897

Cappellacci et al (2005) Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. J.Med.Chem. 48 1550 PMID: 15743197

If you know of a relevant reference for 2'-MeCCPA, please let us know.

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关键词: 2'-MeCCPA, 2'-MeCCPA supplier, selective, potent, A1, receptor, agonists, Receptors, adenosines, 2-MeCCPA, Adenosine, 2281, Tocris Bioscience

2 篇 2'-MeCCPA 的引用文献

引用文献是使用了 Tocris 产品的出版物。 2'-MeCCPA 的部分引用包括：

Yang et al (2010) Adenosine mediated desensitization of cAMP signaling enhances T-cell responses. Eur J Immunol 40 449 PMID: 19950175

Liu et al (2018) Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect. Brain Res 1700 47 PMID: 29935155

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