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说明： Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable
化学名： 2-(3-Mercaptopropyl)pentanedioic acid
生物活性 for 2-MPPA
2-MPPA is a selective glutamate carboxypeptidase II (GCP II) inhibitor (IC50 = 90 nM). Selective for GCP II over NMDA, kainate and AMPA glutamate receptors and MMP-1, -2, -3, -7, -9, ACE and NEP metalloproteases. Antinociceptive in a rat model of neuropathic pain and protects against motor neuron death in familial amyotrophic lateral sclerosis mice. Orally bioavailable.
技术数据 for 2-MPPA
| 分子量 | 206.26 |
| 公式 | C8H14O4S |
| 储存 | Store at -20°C |
| CAS Number | 254737-29-6 |
| PubChem ID | 10198171 |
| InChI Key | FNLNSQHJKVQCBP-UHFFFAOYSA-N |
| Smiles | SCCCC(C(O)=O)CCC(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for 2-MPPA
参考文献 for 2-MPPA
参考文献是支持产品生物活性的出版物。
Majer et al (2003) Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J.Med.Chem. 46 1989 PMID: 12723961
Ghadge et al (2003) Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models. Proc.Natl.Acad.Sci.U.S.A. 100 9554 PMID: 12876198
Vornov et al (2013) Pharmacokinetics and pharmacodynamics of the glutamate carboxypeptidase II inhibitor 2-MPPA show prolonged alleviation of neuropathic pain through an indirect mechanism. J.Pharmacol.Exp.Ther. 346 406 PMID: 23776202
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关键词: 2-MPPA, 2-MPPA supplier, selective, glutamate, carboxypeptidase, 2, II, GCP2, GCPII, inhibitors, inhibits, neuroprotective, antinociceptive, orally, bioavailable, Carboxypeptidase, Miscellaneous, Glutamate, 5033, Tocris Bioscience
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