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FMK 9a

Cat. No. 7496 Submit a Review Datasheet / COA / SDS
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Description: Potent ATG4B/autophagin-1 inhibitor; also inhibits calpain and cathepsin B
Chemical Name: N-[(1S)-2-[(3-Fluoro-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-1-naphthalenecarboxamide
Purity: ≥90% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for FMK 9a

FMK 9a is a potent ATG4B/autophagin-1 inhibitor (IC50 values are 73 nM and 80 nM in cell-based LRA and TR-FRET assays, respectively). Also inhibits calpain and cathepsin B (IC50 values are 96 nM and 200 nM, respectively).

Technical Data for FMK 9a

M. Wt 392.43
Formula C23H21FN2O3
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 1955550-51-2
PubChem ID 127020966
InChI Key VMVOHHPQIAPYHG-NRFANRHFSA-N
Smiles FCC(CNC([C@@H](NC(C1=CC=CC2=C1C=CC=C2)=O)CC3=CC=CC=C3)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FMK 9a

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.24 100

Preparing Stock Solutions for FMK 9a

The following data is based on the product molecular weight 392.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References for FMK 9a

References are publications that support the biological activity of the product.

Qiu et al (2016) Discovery of fluoromethylketone-based peptidomimetics as covalent ATG4B (autophagin-1) inhibitors. ACS Med.Chem.Lett. 7 802 PMID: 27563406

If you know of a relevant reference for FMK 9a, please let us know.

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Citations for FMK 9a

Citations are publications that use Tocris products.

Currently there are no citations for FMK 9a. Do you know of a great paper that uses FMK 9a from Tocris? Please let us know.

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