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3,5-DHBA

Cat. No. 4599 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective HCA1 agonist
化学名： 3,5-Dihydroxybenzoic acid
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 3,5-DHBA

3,5-DHBA is a selective agonist of hydroxycarboxylic acid receptor 1 (HCA1, also known as GPR81) (EC50 ~150 μM). Inhibits lipolysis in wild-type mouse adipocytes. Displays minimal activity at HCA2 (at concentrations >10 mM) and no activity at HCA3, free fatty acid receptor (FFAR) 2 or FFAR3.

技术数据 for 3,5-DHBA

分子量 154.12
公式 C7H6O4
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 99-10-5
PubChem ID 7424
InChI Key UYEMGAFJOZZIFP-UHFFFAOYSA-N
Smiles OC1=CC(O)=CC(C(O)=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 3,5-DHBA

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 15.41 100
DMSO 15.41 100

制备储备液 for 3,5-DHBA

以下数据基于产品分子量 154.12。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 6.49 mL 32.44 mL 64.88 mL
5 mM 1.3 mL 6.49 mL 12.98 mL
10 mM 0.65 mL 3.24 mL 6.49 mL
50 mM 0.13 mL 0.65 mL 1.3 mL

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参考文献 for 3,5-DHBA

参考文献是支持产品生物活性的出版物。

Liu et al (2012) 3,5-dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J.Pharmacol.Exp.Ther. 341 794 PMID: 22434674

If you know of a relevant reference for 3,5-DHBA, please let us know.

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关键词: 3,5-DHBA, 3,5-DHBA supplier, gpr81, orphan, receptors, hca1, hydroxycarboxylic, acid, receptor, 1, selective, agonists, Hydroxycarboxylic, Acid, Receptors, 4599, Tocris Bioscience

1 篇 3,5-DHBA 的引用文献

引用文献是使用了 Tocris 产品的出版物。 3,5-DHBA 的部分引用包括：

Taesik et al (2020) Hydrocarboxylic acid receptor 1 in BAT regulates glucose uptake in mice fed a high-fat diet. PLoS One 15 e0228320 PMID: 31999787

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