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Submit Review3-Bromopyruvate
说明： MCT1 inhibitor; also inhibits hexokinase II
化学名： 3-Bromo-2-oxopropanoic acid
生物活性 for 3-Bromopyruvate
3-Bromopyruvate is a monocarboxylate transporter (MCT1) inhibitor (IC50 = 14.7 μM, 24.2 μM and 28.6 μM in SiHa, UM-UC-3, and HCT-116 human cancer cell lines, respectively). 3-Bromopyruvate shows antitumor activity in vitro and in vivo. 3-Bromopyruvate is also an inhibitor of hexokinase II, and decreases apoptosis in dopaminergic neurons in Parkinson's disease models in vitro and in vivo.
技术数据 for 3-Bromopyruvate
| 分子量 | 166.96 |
| 公式 | C3H3BrO3 |
| 储存 | Store at -20°C |
| CAS Number | 1113-59-3 |
| PubChem ID | 70684 |
| InChI Key | PRRZDZJYSJLDBS-UHFFFAOYSA-N |
| Smiles | O=C(O)C(=O)CBr |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 3-Bromopyruvate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 16.7 | 100 |
制备储备液 for 3-Bromopyruvate
以下数据基于产品分子量 166.96。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.99 mL | 29.95 mL | 59.89 mL |
| 5 mM | 1.2 mL | 5.99 mL | 11.98 mL |
| 10 mM | 0.6 mL | 2.99 mL | 5.99 mL |
| 50 mM | 0.12 mL | 0.6 mL | 1.2 mL |
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产品说明书 for 3-Bromopyruvate
参考文献 for 3-Bromopyruvate
参考文献是支持产品生物活性的出版物。
Vander Linden et al (2021) Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition. Cell Rep. 35 109202 PMID: 34077729
Li et al (2022) Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease. Neurobiol. Dis. 163 105605 PMID: 34973450
If you know of a relevant reference for 3-Bromopyruvate, please let us know.
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关键词: 3-Bromopyruvate, 3-Bromopyruvate supplier, MCT1, monocarboxylate, transporters, 1, inhibitors, inhibits, anticancer, hexokinase, antitumor, antitumour, apoptosis, Parkinsons, disease, Monocarboxylate, Transporters, Hexokinases, 7512, Tocris Bioscience
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