(-)-[3R,4S]-Chromanol 293B

Cat. No. 1475 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： I_Ks blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)

化学名： N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide

纯度： ≥99% (HPLC)

引用文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (-)-[3R,4S]-Chromanol 293B

(-)-[3R,4S]-Chromanol 293B is a enantiomer that selectively inhibits the slow component of delayed rectifier K⁺ current (I_Ks). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC₅₀ values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at K_V11.1 (hERG) channels (IC₅₀ > 30 μM).

Racemate also available.

化合物库 for (-)-[3R,4S]-Chromanol 293B

(-)-[3R,4S]-Chromanol 293B is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for (-)-[3R,4S]-Chromanol 293B

分子量	324.39
公式	C₁₅H₂₀N₂O₄S
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	163163-24-4
PubChem ID	121846
InChI Key	HVSJHHXUORMCGK-UONOGXRCSA-N
Smiles	CCS(=O)(=O)N(C)[C@@H]1[C@@H](O)C(C)(C)OC2=C1C=C(C=C2)C#N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (-)-[3R,4S]-Chromanol 293B

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	32.44	100 温和加热
	DMSO	32.44	100 温和加热

制备储备液 for (-)-[3R,4S]-Chromanol 293B

以下数据基于产品分子量 324.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.08 mL	15.41 mL	30.83 mL
5 mM	0.62 mL	3.08 mL	6.17 mL
10 mM	0.31 mL	1.54 mL	3.08 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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产品说明书 for (-)-[3R,4S]-Chromanol 293B

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (-)-[3R,4S]-Chromanol 293B

参考文献是支持产品生物活性的出版物。

Lerche et al (2001) Molecular impact of MinK on the enantiospecific block of I_Ks by chromanols. Br.J.Pharmacol. 131 1503 PMID: 11139424

Seebohm et al (2001) A kinetic study on the stereospecific inhibition of KCNQ1 and I_Ks by the chromanol 293B. Br.J.Pharmacol. 134 1647 PMID: 11739240

Yang et al (2000) Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels. J.Pharmacol.Exp.Ther. 294 955 PMID: 10945846

If you know of a relevant reference for (-)-[3R,4S]-Chromanol 293B, please let us know.

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关键词: (-)-[3R,4S]-Chromanol 293B, (-)-[3R,4S]-Chromanol 293B supplier, IKs, blockers, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, (-)-[3R4S]-Chromanol293B, Voltage-Gated, 1475, Tocris Bioscience

3 篇 (-)-[3R,4S]-Chromanol 293B 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (-)-[3R,4S]-Chromanol 293B 的部分引用包括：

Purtell et al (2012) The KCNQ1-KCNE2 K+ channel is required for adequate thyroid I- uptake. Neuropharmacology 26 3252 PMID: 22549510

Ma et al (2011) High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. FASEB J 301 H2006 PMID: 21890694

Song et al (2022) Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome. Nat.Card.Res. 1 142 PMID: 36051854

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