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Submit Review4-Chlorophenylguanidine hydrochloride is a potent and specific inhibitor of urokinase. Also a positive allosteric modulator at acid sensing ion channel 3 (ASIC3), which increases its pH sensitivity.
分子量 | 206.07 |
公式 | C7H8ClN3.HCl |
储存 | Store at RT |
纯度 | ≥98% (HPLC) |
CAS Number | 14279-91-5 |
PubChem ID | 44134626 |
InChI Key | RMFZXBDENVVLSL-UHFFFAOYSA-N |
Smiles | Cl.NC(=N)NC1=CC=C(Cl)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 100 |
以下数据基于产品分子量 206.07。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 4.85 mL | 24.26 mL | 48.53 mL |
5 mM | 0.97 mL | 4.85 mL | 9.71 mL |
10 mM | 0.49 mL | 2.43 mL | 4.85 mL |
50 mM | 0.1 mL | 0.49 mL | 0.97 mL |
参考文献是支持产品生物活性的出版物。
Yang et al (1990) Selective inhibition of urok. by substituted phenylguanidines: quantitative structure-activity relationship analyses. J.Med.Chem. 33 2956 PMID: 2231595
Agharkar & Gonzales (2017) 4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator. J.Pharmacol.Sci. 133 184 PMID: 28259560
If you know of a relevant reference for 4-Chlorophenylguanidine hydrochloride, please let us know.
关键词: 4-Chlorophenylguanidine hydrochloride, 4-Chlorophenylguanidine hydrochloride supplier, Urokinase, inhibitors, inhibits, Proteases, Proteinases, upa, PAM, ASIC, 0442, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 4-Chlorophenylguanidine hydrochloride 的部分引用包括:
Agharkar & Gonzales 4-Chlorophenylguanidine is an ASIC3 agonist and positive allosteric modulator. J.Pharmacol.Sci. 133 184 PMID: 28259560
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