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4-CMTB

Cat. No. 4642 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： FFA2 agonist; also exhibits positive allosteric modulatory activity
化学名： 4-chloro-α-(1-methylethyl)-N-2-thiazolylbenzeneacetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 4-CMTB

4-CMTB is a free fatty acid receptor FFA2 agonist (pEC50 = 6.38) and positive allosteric modulator. Binds at a site distinct from the orthosteric site; modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2).

化合物库 for 4-CMTB

4-CMTB is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for 4-CMTB

分子量 294.8
公式 C14H15ClN2OS
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 300851-67-6
PubChem ID 4307629
InChI Key AZYDQCGCBQYFSE-UHFFFAOYSA-N
Smiles ClC1=CC=C(C(C(C)C)C(NC2=NC=CS2)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 4-CMTB

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.48 100
ethanol 5.9 20

制备储备液 for 4-CMTB

以下数据基于产品分子量 294.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.39 mL 16.96 mL 33.92 mL
5 mM 0.68 mL 3.39 mL 6.78 mL
10 mM 0.34 mL 1.7 mL 3.39 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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参考文献 for 4-CMTB

参考文献是支持产品生物活性的出版物。

Smith et al (2011) Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol.Pharmacol. 80 163 PMID: 21498659

Milligan et al (2009) Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3. Br.J.Pharmacol. 158 146 PMID: 19719777

If you know of a relevant reference for 4-CMTB, please let us know.

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关键词: 4-CMTB, 4-CMTB supplier, free, fatty, acid, receptors, FFA, FFA2, agonists, positive, allosteric, modulators, pams, Free, Fatty, Acid, Receptors, 4642, Tocris Bioscience

3 篇 4-CMTB 的引用文献

引用文献是使用了 Tocris 产品的出版物。 4-CMTB 的部分引用包括：

Martin-Gallausiaux et al (2019) Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells. Front Immunol 9 2838 PMID: 30619249

Martin-Gallausiaux et al (2018) Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells. Sci Rep 8 9742 PMID: 29950699

Marinelli et al (2019) Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells Sci.Rep. 9 643 PMID: 30679727

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