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说明： Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate
化学名： 4-Iodo-6-phenylpyrimidine
纯度： ≥98% (HPLC)
生物活性 for 4-IPP
4-IPP is an inhibitor of macrophage migration inhibitory factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro.
技术数据 for 4-IPP
| 分子量 | 282.08 |
| 公式 | C10H7IN2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 41270-96-6 |
| PubChem ID | 817368 |
| InChI Key | ZTCJXHNJVLUUMR-UHFFFAOYSA-N |
| Smiles | IC1=NC=NC(C2=CC=CC=C2)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 4-IPP
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 28.21 | 100 | |
| ethanol | 14.1 | 50 |
制备储备液 for 4-IPP
以下数据基于产品分子量 282.08。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.55 mL | 17.73 mL | 35.45 mL |
| 5 mM | 0.71 mL | 3.55 mL | 7.09 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.55 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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产品说明书 for 4-IPP
参考文献 for 4-IPP
参考文献是支持产品生物活性的出版物。
Winner et al (2008) A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Res. 68 7253 PMID: 18794110
If you know of a relevant reference for 4-IPP, please let us know.
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关键词: 4-IPP, 4-IPP supplier, macrophage, migration, inhibitory, factors, MIF, inhibitors, inhibits, suicide, substrates, cytokines, 4IPP, Cytokines, 3429, Tocris Bioscience
4 篇 4-IPP 的引用文献
引用文献是使用了 Tocris 产品的出版物。 4-IPP 的部分引用包括：
Justin D et al (2020) Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression. Front Immunol 11 1191 PMID: 32625208
Subbannayya et al (2015) Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer. J Biol Chem 15 843 PMID: 26530123
Salazar et al (2014) The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation. Mol Cancer 13 198 PMID: 25168820
Takahashi et al (2013) Macrophage migration inhibitory factor and stearoyl-CoA desaturase 1: potential prognostic markers for soft tissue sarcomas based on bioinformatics analyses. PLoS One 8 e78250 PMID: 24167613
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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