Cytokines
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.
Cytokine Agonists |
|
|---|---|
| Cat. No. | 产品名称/活性 |
| 6583 | UCLA GP130 2 |
| gp130 agonist; brain penetrant and neuroprotectant | |
Cytokine Inhibitors |
|
| Cat. No. | 产品名称/活性 |
| 5430 | AS 2444697 |
| Potent and selective IRAK4 inhibitor | |
| 7820 | CU-76 |
| Selective cGAS-STING pathway inhibitor | |
| 4288 | ISO 1 |
| Macrophage migration inhibitory factor (MIF) inhibitor | |
| 7320 | Methoxyluteolin |
| Inhibitor of pro-inflammatory mediator release from mast cells | |
| 4963 | SC 144 hydrochloride |
| gp130 inhibitor; blocks cytokine-triggered gp130 signaling | |
Cytokine Blockers |
|
| Cat. No. | 产品名称/活性 |
| 6965 | CGI 1746 |
| Blocks production of cytokines IL-1β TNFα and IL-6; potent inhibitor of BTK | |
Degraders |
|
| Cat. No. | 产品名称/活性 |
| 7503 | MD13 |
| Potent MIF Degrader (PROTAC®) | |
Controls |
|
| Cat. No. | 产品名称/活性 |
| 7504 | MD15 |
| Negative control for MD13 (Cat. No. 7503) | |
Other |
|
| Cat. No. | 产品名称/活性 |
| 7283 | Apilimod dimesylate |
| Inhibits production of IL-12 and IL-23; potent and selective PIKfyve inhibitor | |
| 6438 | BRD 6989 |
| IL-10 production enhancer; Cdk8 inhibitor | |
| 4316 | Bropirimine |
| Immunomodulatory and antitumor compound | |
| 4204 | BTZO 1 |
| MIF binder | |
| 4400 | (±)-CPSI 1306 |
| Reported macrophage migration inhibitory factor (MIF) inhibitor | |
| 5479 | CRID3 sodium salt |
| Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production | |
| 2471 | ER 27319 maleate |
| Inhibits TNF-α production | |
| 1798 | Gabexate mesylate |
| Inhibits TNF-α production. Also antithrombotic agent | |
| 3270 | GIT 27 |
| Immunomodulator; reduces production of pro-inflammatory cytokines | |
| 7866 | IDR 1002 |
| Innate Defence Regulator Peptide | |
| 5126 | iMDK |
| Suppressor of MDK expression; inhibits PI 3-K signaling | |
| 3429 | 4-IPP |
| Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate | |
| 5185 | JTE 607 dihydrochloride |
| Cytokine release inhibitor; anti-inflammatory | |
| 6305 | Lenalidomide |
| TNF-α inhibitor; inhibits angiogenesis; also cereblon binder | |
| 1093 | Pirfenidone |
| Antifibrotic agent; regulates cytokine levels in vivo | |
| 6302 | Pomalidomide |
| TNF-α inhibitor; also cereblon ubiquitination inhibitor and antiangiogenic | |
| 0652 | Thalidomide |
| TNF-α synthesis inhibitor; also binds cereblon | |
| 7937 | Trofinetide |
| Suppressor of IL-1β, TNF-α, IFN-γ and E-selectin expression; IGF-1 synthetic analog | |
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases.
Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems.
Cytokines can be classified into two groups: pro- and anti-inflammatory. Proinflammatory cytokines, including IFNγ, IL-1, IL-6 and TNF-α, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.
Literature for Cytokines
Tocris offers the following scientific literature for Cytokines to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.
Cytokine Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| Interleukins | ||||
| Il-1α | Human | IL1A | NM_000575 | P01583 |
| Mouse | Il1a | NM_010554 | P01582 | |
| Rat | Il1a | NM_017019 | P16598 | |
| IL-1β | Human | IL1B | NM_000576 | P01584 |
| Mouse | Il1b | NM_008361 | P10749 | |
| Rat | Il1b | NM_031512 | Q5BKB0 | |
| IL-1δ | Human | IL1F5 | NM_173170 | Q9UBH0 |
| Mouse | Il1f5 | NM_019451 | Q62470 | |
| Rat | Il1f5 | NM_001107814 | XP_231101 | |
| IL-1ε | Human | IL1F6 | NM_014440 | Q9UHA7 |
| Mouse | Il1f6 | NM_019450 | Q9JLA2 | |
| Rat | Il1f6 | NM_001106554 | XP_231099 | |
| IL-1ζ | Human | IL1F7 | NM_014439 | Q9NZH6 |
| IL-1η | Human | IL1F8 | NM_014438 | Q9NZH7 |
| Mouse | Il1f8 | NM_027163 | Q9D6Z6 | |
| Rat | Il1f8 | NM_001108570 | XP_342378 | |
| IL-1, family member 9 | Human | IL1F9 | NM_019618 | Q9NZH8 |
| Mouse | Il1f9 | NM_153511 | Q8R460 | |
| Rat | Il1f9 | NM_001113790 | XP_575079 | |
| IL-1θ | Human | IL1F10 | NM_173161 | Q8WWZ1 |
| Mouse | Il1f10 | NM_153077 | Q8R459 | |
| Rat | Il1f10 | NM_001108571 | XP_342379 | |
| IL-2 | Human | IL2 | NM_000586 | P60568 |
| Mouse | Il2 | NM_008366 | P04351 | |
| Rat | Il2 | NM_053836 | P17108 | |
| IL-3 | Human | IL3 | NM_000588 | P08700 |
| Mouse | Il3 | NM_010556 | P01586 | |
| Rat | Il3 | NM_031513 | P04823 | |
| IL-4 | Human | IL4 | NM_000589 | P05112 |
| Mouse | Il4 | NM_021283 | P07750 | |
| Rat | Il4 | NM_201270 | P20096 | |
| IL-5 | Human | IL5 | NM_000879 | P05113 |
| Mouse | Il5 | NM_010558 | P04401 | |
| Rat | Il5 | NM_021834 | Q08125 | |
| IL-6 | Human | IL6 | NM_000600 | P05231 |
| Mouse | Il6 | NM_031168 | P08505 | |
| Rat | Il6 | NM_012589 | P20607 | |
| IL-7 | Human | IL7 | NM_000880 | P13232 |
| Mouse | Il7 | NM_008371 | P10168 | |
| Rat | Il7 | NM_013110 | P56478 | |
| IL-8 | Human | IL8 | NM_000584 | P10145 |
| IL-9 | Human | IL9 | NM_000590 | P15248 |
| Mouse | Il9 | NM_008373 | P15247 | |
| Rat | Il9 | NM_001105747 | XP_341488 | |
| IL-10 | Human | IL10 | NM_000572 | P22301 |
| Mouse | Il10 | NM_010548 | P18893 | |
| Rat | Il10 | NM_012854 | P29456 | |
| IL-11 | Human | IL11 | NM_000641 | P20809 |
| Mouse | Il11 | NM_008350 | P47873 | |
| Rat | Il11 | NM_133519 | Q99MF5 | |
| IL-12A | Human | IL12A | NM_000882 | P29459 |
| Mouse | Il12a | NM_008351 | P43431 | |
| Rat | Il12a | NM_053390 | Q9R103 | |
| IL-12B | Human | IL12B | NM_002187 | P29460 |
| Mouse | Il12b | NM_008352 | P43432 | |
| Rat | Il12b | NM_022611 | Q62712 | |
| IL-13 | Human | IL13 | NM_002188 | P35225 |
| Mouse | Il13 | NM_008355 | P20109 | |
| Rat | Il13 | NM_053828 | P42203 | |
| IL-15 | Human | IL15 | NM_000585 | P40933 |
| Mouse | Il15 | NM_008357 | P48346 | |
| Rat | Il15 | NM_013129 | P97604 | |
| IL-16 | Human | IL16 | NM_172217 | Q14005 |
| Mouse | Il16 | NM_010551 | O54824 | |
| Rat | Il16 | NM_001105749 | XP_218851 | |
| IL-17A | Human | IL17A | NM_002190 | Q16552 |
| Mouse | Il17a | NM_010552 | Q62386 | |
| Rat | Il17a | L13839 | Q61453 | |
| IL-17B | Human | IL17B | NM_014443 | Q9UHF5 |
| Mouse | Il17b | NM_019508 | Q9QXT6 | |
| Rat | Il17b | XM_341621 | Q9EQI7 | |
| IL-17C | Human | IL17C | NM_013278 | Q9P0M4 |
| Mouse | Il17c | NM_145834 | NP_665833 | |
| Rat | Il17c | XM_001078615 | XP_001078615 | |
| IL-17D | Human | IL17D | NM_138284 | Q8TAD2 |
| Mouse | Il17d | NM_145837 | NP_665836 | |
| Rat | Il17d | XM_001079675 | XP_001079675 | |
| IL-17F | Human | IL17F | NM_052872 | Q96PD4 |
| Mouse | Il17f | NM_145856 | NP_665855 | |
| Rat | Il17f | NM_001015011 | Q5BJ95 | |
| IL-18 | Human | IL18 | NM_001562 | Q14116 |
| Mouse | Il18 | NM_008360 | P70380 | |
| Rat | Il18 | NM_019165 | P97636 | |
| IL-19 | Human | IL19 | NM_153758 | Q9UHD0 |
| Mouse | Il19 | NM_001009940 | Q8CJ70 | |
| Rat | Il19 | XM_001060482 | XP_001060482 | |
| IL-20 | Human | IL20 | NM_018724 | Q9NYY1 |
| Mouse | Il20 | NM_021380 | Q9JKV9 | |
| Rat | Il20 | NM_001143881 | XP_001060362 | |
| IL-21 | Human | IL21 | NM_021803 | Q9HBE4 |
| Mouse | Il21 | NM_021782 | Q9ES17 | |
| Rat | Il21 | NM_001108943 | XP_345202 | |
| IL-22 | Human | IL22 | NM_020525 | Q9GZX6 |
| Mouse | Il22 | NM_016971 | Q9JJY9 | |
| IL-23A | Human | IL23A | NM_016584 | Q9NPF7 |
| Mouse | Il23a | NM_031252 | Q9EQ14 | |
| Rat | Il23a | NM_130410 | Q91Z84 | |
| IL-24 | Human | IL24 | NM_006850 | Q13007 |
| Mouse | Il24 | NM_053095 | Q925S4 | |
| Rat | Il24 | NM_133311 | Q9JI24 | |
| IL-25 | Human | IL25 | NM_172314 | Q9H293 |
| Mouse | Il25 | NM_080729 | NP_542767 | |
| Rat | Il25 | XM_577423 | XP_577423 | |
| IL-26 | Human | IL26 | NM_018402 | Q9NPH9 |
| IL-27 | Human | IL27 | NM_145659 | Q8NEV9 |
| Mouse | Il27 | NM_145636 | Q8K3I6 | |
| Rat | Il27 | XM_344962 | XP_344963 | |
| IL-28A | Human | IL28A | NM_172138 | Q8IZJ0 |
| Mouse | Il28a | NM_001024673 | Q4VK74 | |
| IL-28B | Human | IL28B | NM_172139 | Q8IZI9 |
| Mouse | Il28b | NM_177396 | Q8CGK6 | |
| IL-29 | Human | IL29 | NM_172140 | Q8IU54 |
| IL-30 | Human | IL31 | NM_001014336 | Q6EBC2 |
| Mouse | Il31 | AK005939 | Q6EAL8 | |
| IL-32 | Human | IL32 | NM_004221 | P24001 |
| IL-33 | Human | IL33 | NM_033439 | O95760 |
| Mouse | Il33 | NM_133775 | Q8BVZ5 | |
| Rat | Il33 | NM_001014166 | Q66H70 | |
| IL-34 | Human | IL34 | NM_152456 | Q6ZMJ4 |
| Mouse | Il34 | NM_029646 | Q8R1R4 | |
| Rat | Il34 | NM_001025766 | Q5DWV2 | |
| Interferons | ||||
| IFN-α1 | Human | IFNA1 | NM_024013 | P01562 |
| Mouse | Ifna1 | NM_010502 | P01572 | |
| Rat | Ifna1 | NM_001014786 | P05011 | |
| IFN-α2 | Human | IFNA2 | NM_000605 | P01563 |
| Mouse | Ifna2 | NM_010503 | P01573 | |
| Rat | Ifna2 | XM_233152 | XP_233152 | |
| IFN-α4 | Human | IFNA4 | NM_021068 | P05014 |
| Mouse | Ifna4 | NM_010504 | P07351 | |
| Rat | Ifna4 | NM_001106667 | XP_233145 | |
| IFN-α5 | Human | IFNA5 | NM_002169 | P01569 |
| Mouse | Ifna5 | NM_010505 | P07349 | |
| IFN-α6 | Human | IFNA6 | NM_021002 | P05013 |
| Mouse | Ifna6 | NM_206871 | P07350 | |
| IFN-α7 | Human | IFNA7 | NM_021057 | P01567 |
| Mouse | Ifna7 | NM_008334 | P06799 | |
| IFN-α8 | Human | IFNA8 | NM_002170 | P32881 |
| IFN-α9 | Human | IFNA10 | NM_002171 | P01566 |
| Mouse | Ifna10 | - | - | |
| IFN-α11 | Mouse | Ifna11 | NM_008333 | Q61716 |
| Rat | Ifna11 | XM_233150 | XP_233150 | |
| IFN-α12 | Mouse | Ifna12 | NM_177361 | Q80SS5 |
| IFN-α13 | Human | IFNA13 | NM_006900 | P01562 |
| Mouse | Ifna13 | NM_177347 | Q80SU4 | |
| Rat | Ifna13 | XM_233147 | - | |
| IFN-α14 | Human | IFNA14 | NM_002172 | P01570 |
| Mouse | Ifna14 | NM_206975 | NP_996858 | |
| IFN-α16 | Human | IFNA16 | NM_002173 | P05015 |
| IFN-α17 | Human | IFNA17 | NM_021268 | P01571 |
| IFN-α21 | Human | IFNA21 | NM_002175 | P01568 |
| IFN-β1 | Human | IFNB1 | NM_002176 | P01574 |
| Mouse | Ifnb1 | NM_010510 | P01575 | |
| Rat | Ifnb1 | NM_019127 | P70499 | |
| IFN-γ | Human | IFNG | NM_000619 | P01579 |
| Mouse | Ifng | NM_008337 | P01580 | |
| Rat | Ifng | NM_138880 | P01581 | |
| IFN-ε | Human | IFNE | NM_176891 | AY190045 |
| Mouse | Ifne | NM_177348 | Q80ZF2 | |
| IFN-κ | Human | IFNK | NM_020124 | Q9P0W0 |
| Mouse | Ifnk | NM_199157 | Q7TSL0 | |
| Rat | Ifnk | NM_001107925 | XP_232873 | |
| IFN-ω | Human | IFNW1 | NM_002177 | P05000 |
| IFN-ζ | Mouse | Ifnz | NM_197889 | NP_922871 |
| Tumor Necrosis Factor | ||||
| TNF-α | Human | TNF | NM_000594 | P01375 |
| Mouse | Tnf | NM_013693 | P06804 | |
| Rat | Tnf | NM_012675 | P16599 | |
Written by Adam P. Cribbs et al.
Our Rheumatoid Arthritis poster summarizes the disease pathology and highlights some of the epigenetic modifications associated with the condition.
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