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4-P-PDOT

Cat. No. 1034 8 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： MT2 antagonist
别名： AH 024
化学名： cis-4-Phenyl-2-propionamidotetralin
纯度： ≥99% (HPLC)
说明书
引用文献 (8)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 4-P-PDOT

4-P-PDOT is a melatonin receptor antagonist, >300-fold selective for the MT2 (vs MT1) subtype.

化合物库 for 4-P-PDOT

4-P-PDOT is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for 4-P-PDOT

分子量 279.38
公式 C19H21NO
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 620170-78-7
PubChem ID 3976006
InChI Key RCYLUNPFECYGDW-UHFFFAOYSA-N
Smiles CCC(=O)NC1CC(C2=CC=CC=C2)C2=C(C1)C=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 4-P-PDOT

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 27.94 100
ethanol 27.94 100

制备储备液 for 4-P-PDOT

以下数据基于产品分子量 279.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.58 mL 17.9 mL 35.79 mL
5 mM 0.72 mL 3.58 mL 7.16 mL
10 mM 0.36 mL 1.79 mL 3.58 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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产品说明书 for 4-P-PDOT

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for 4-P-PDOT

参考文献是支持产品生物活性的出版物。

Dubocovich et al (1997) Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 355 365 PMID: 9089668

Dubocovich et al (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50 PMID: 7762083

If you know of a relevant reference for 4-P-PDOT, please let us know.

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关键词: 4-P-PDOT, 4-P-PDOT supplier, MT2, antagonists, Receptors, Melatonin, AH024, AH, 024, (MT), 1034, Tocris Bioscience

8 篇 4-P-PDOT 的引用文献

引用文献是使用了 Tocris 产品的出版物。 4-P-PDOT 的部分引用包括：

Faria et al (2013) Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats. Am J Physiol Endocrinol Metab 305 E230 PMID: 23695212

Zhao et al (2010) Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells. J Physiol 588 2605 PMID: 20519319

Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478 PMID: 20696141

Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Pharmacol Exp Ther 336 127 PMID: 20959363

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