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Discontinued Product
4234 has been discontinued.
说明： α7 nAChR agonist; acts at an allosteric site
化学名： 4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
纯度： ≥98% (HPLC)
生物活性 for 4BP-TQS
4BP-TQS is an allosteric agonist at α7 nAChR. Binds at a separate site and exhibits more efficacious receptor agonism compared to acetylcholine (Cat. No. 2809), displays 8-fold lower EC50 value and 45-fold larger maximal response.
技术数据 for 4BP-TQS
| 分子量 | 405.31 |
| 公式 | C18H17BrN2O2S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 360791-49-7 |
| PubChem ID | 2857838 |
| InChI Key | YNCXHXYZTLIZTO-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(C2NC(C=CC(S(=O)(N)=O)=C4)=C4C3C2CC=C3)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for 4BP-TQS
参考文献 for 4BP-TQS
参考文献是支持产品生物活性的出版物。
Gill et al (2011) Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci.U.S.A. 108 5867 PMID: 21436053
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关键词: 4BP-TQS, 4BP-TQS supplier, alpha7, nAChR, a7, agonists, nicotinic, α7, Nicotinic, (a7), Receptors, 4234, Tocris Bioscience
1 篇 4BP-TQS 的引用文献
引用文献是使用了 Tocris 产品的出版物。 4BP-TQS 的部分引用包括：
Zhang et al (2015) Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor. Proc Natl Acad Sci U S A 10 e0137588 PMID: 26340537
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.