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Submit Review5,7-Dichlorokynurenic acid
说明： Potent NMDA antagonist; acts at glycine site
化学名： 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid
纯度： ≥98% (HPLC)
生物活性 for 5,7-Dichlorokynurenic acid
5,7-Dichlorokynurenic acid is a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine).
Sodium Salt also available.
化合物库 for 5,7-Dichlorokynurenic acid
5,7-Dichlorokynurenic acid is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for 5,7-Dichlorokynurenic acid
| 分子量 | 258.06 |
| 公式 | C10H5Cl2NO3 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 131123-76-7 |
| PubChem ID | 1779 |
| InChI Key | BGKFPRIGXAVYNX-UHFFFAOYSA-N |
| Smiles | OC(=O)C1=NC2=CC(Cl)=CC(Cl)=C2C(O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 5,7-Dichlorokynurenic acid
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 1eq. NaOH | 100 | ||
| DMSO | 100 |
制备储备液 for 5,7-Dichlorokynurenic acid
以下数据基于产品分子量 258.06。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.88 mL | 19.38 mL | 38.75 mL |
| 5 mM | 0.78 mL | 3.88 mL | 7.75 mL |
| 10 mM | 0.39 mL | 1.94 mL | 3.88 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
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产品说明书 for 5,7-Dichlorokynurenic acid
参考文献 for 5,7-Dichlorokynurenic acid
参考文献是支持产品生物活性的出版物。
Baron et al (1990) Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol. 38 554 PMID: 2172769
Moore et al (1990) Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor. Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I 29
If you know of a relevant reference for 5,7-Dichlorokynurenic acid, please let us know.
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关键词: 5,7-Dichlorokynurenic acid, 5,7-Dichlorokynurenic acid supplier, Potent, NMDA, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 0286, Tocris Bioscience
4 篇 5,7-Dichlorokynurenic acid 的引用文献
引用文献是使用了 Tocris 产品的出版物。 5,7-Dichlorokynurenic acid 的部分引用包括：
Kenny et al (2009) The integrity of the glycine co-agonist binding site of N-MthD.-aspartate receptors is a functional quality control checkpoint for cell surface delivery. J Biol Chem 284 324 PMID: 18990687
Stevens et al (2010) Light-evoked NMDA receptor-mediated currents are reduced by blocking D-serine synthesis in the salamander retina. Cell Commun Signal 21 239 PMID: 20101193
Adamsky et al (2018) Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement. Cell 174 59 PMID: 29804835
Astorga et al (2015) An excitatory GABA loop operating in vivo. Front Cell Neurosci 9 275 PMID: 26236197
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