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Submit Review5-Azacytidine
说明： DNA methyltransferase inhibitor
化学名： 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
纯度： ≥98% (HPLC)
生物活性 for 5-Azacytidine
5-Azacytidine is a DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.
化合物库 for 5-Azacytidine
5-Azacytidine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for 5-Azacytidine
| 分子量 | 244.2 |
| 公式 | C8H12N4O5 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 320-67-2 |
| PubChem ID | 9444 |
| InChI Key | NMUSYJAQQFHJEW-KVTDHHQDSA-N |
| Smiles | O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(N=C(N)N=C2)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 5-Azacytidine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 12.21 | 50 | |
| DMSO | 24.42 | 100 |
制备储备液 for 5-Azacytidine
以下数据基于产品分子量 244.2。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.1 mL | 20.48 mL | 40.95 mL |
| 5 mM | 0.82 mL | 4.1 mL | 8.19 mL |
| 10 mM | 0.41 mL | 2.05 mL | 4.1 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.82 mL |
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产品说明书 for 5-Azacytidine
参考文献 for 5-Azacytidine
参考文献是支持产品生物活性的出版物。
Schneider-Stock et al (2005) 5-aza-Cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. J.Pharmacol.Exp.Ther. 312 525 PMID: 15547111
Mikkelsen et al (2008) Dissecting direct reprogramming through integrative genomic analysis. Nature 454 49 PMID: 18509334
Qian et al (2012) 5-Azacytidine induces cardiac differentiation of human umbilical cord-derived mesenchymal stem cells by activating extracellular regulated kinase. Stem Cells Dev. 21 67 PMID: 21476855
If you know of a relevant reference for 5-Azacytidine, please let us know.
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关键词: 5-Azacytidine, 5-Azacytidine supplier, DNA, methyltransferases, methylation, inhibits, inhibitors, DNMT, mesenchymal, stem, cells, reprogramming, differentiation, differentiating, cardiomyocytes, epigenetics, Methyltransferases, Stem, Cell, Reprogramming, Mesenchymal, Cells, Cardiomyocyte, 3842, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Azacitidine, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
6 篇 5-Azacytidine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 5-Azacytidine 的部分引用包括：
Chong et al (2013) Progenitor cells identified by PDGFR-α expression in the developing and diseased human heart. Cell Res 22 1932 PMID: 23391309
Perera et al (2009) Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS One 4 e4488 PMID: 19221603
Linscott and Chung (2019) TET1 regulates fibroblast growth factor 8 transcription in Gn releasing hormone neurons. PLoS One 14 e0220530 PMID: 31361780
Bhuvanagiri et al (2014) 5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion. EMBO Mol Med 6 1593 PMID: 25319547
Donald J et al (2017) Epigenetic modifiers upregulate MHC II and impede ovarian cancer tumor growth. Oncotarget 8 44159-44170 PMID: 28498806
Chandrakanthan et al (2016) PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells Proc Natl Acad Sci U S A 113 E2306 PMID: 27044077
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Epigenetics in Cancer Research Product Guide
This product guide reviews some of the main areas in cancer epigenetics research and lists around 120 products that can be used for the main epigenetic targets including:
- Histone Methylation
- Histone Acetylation
- DNA Methylation
- Ubiquitination
- Bromodomains
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.