Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review5-Fluorouracil
说明： Thymidylate synthetase inhibitor
别名： 5-FU
化学名： 5-Fluoro-2,4-(1H,3H)-pyrimidinedione
纯度： ≥99% (HPLC)
生物活性 for 5-Fluorouracil
5-Fluorouracil is an anticancer agent. Metabolized to form fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine (FUTP). FdUMP inhibits thymidylate synthase, causing a reduction in dTMP synthesis. FUTP and FdUTP are misincorporated into RNA and DNA respectively.
技术数据 for 5-Fluorouracil
| 分子量 | 130.08 |
| 公式 | C4H3FN2O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 51-21-8 |
| PubChem ID | 3385 |
| InChI Key | GHASVSINZRGABV-UHFFFAOYSA-N |
| Smiles | O=C1C(F)=CNC(N1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 5-Fluorouracil
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 13.01 | 100 | |
| ethanol | 1.3 | 10 |
制备储备液 for 5-Fluorouracil
以下数据基于产品分子量 130.08。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 7.69 mL | 38.44 mL | 76.88 mL |
| 5 mM | 1.54 mL | 7.69 mL | 15.38 mL |
| 10 mM | 0.77 mL | 3.84 mL | 7.69 mL |
| 50 mM | 0.15 mL | 0.77 mL | 1.54 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for 5-Fluorouracil
参考文献 for 5-Fluorouracil
参考文献是支持产品生物活性的出版物。
Ghoshal and Jacob (1997) An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug. Biochem.Pharmacol. 53 1569 PMID: 9264308
Peters et al (2002) Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. Biochim.Biophys.Acta. 1587 194 PMID: 12084461
Longley et al (2003) 5-Fluorouracil: mechanisms of action and clinical strategies. Nat.Rev.Cancer 3 330 PMID: 12724731
If you know of a relevant reference for 5-Fluorouracil, please let us know.
按产品操作查看相关产品
关键词: 5-Fluorouracil, 5-Fluorouracil supplier, inhibitors, inhibits, RNA, DNA, synthesis, thymidylate, synthetases, Synthases, antimetabolites, 5-FU, chemotherapeutics, DNA,, and, Protein, Synthesis, Thymidylate, Synthetase, 3257, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Fluorouracil, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
2 篇 5-Fluorouracil 的引用文献
引用文献是使用了 Tocris 产品的出版物。 5-Fluorouracil 的部分引用包括：
Fukushima et al (2015) Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line. Cancer Sci 106 1000 PMID: 26017781
Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641 PMID: 24265703
您是否知道使用了 Tocris 5-Fluorouracil 的优秀论文？ 请告知我们.
5-Fluorouracil 的评论
目前没有该产品的评论。 Be the first to review 5-Fluorouracil and earn rewards!
Have you used 5-Fluorouracil?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cancer Metabolism Research Product Guide
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Glycolysis
- Tricarboxylic Acid Cycle
- Lipidogenesis
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Pathways for 5-Fluorouracil
Apoptosis Signaling Pathway
Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.