Apoptosis Signaling Pathway
RTK Trk
Receptor Raf Ras IAP IAP AIF MEK
1/2 ERK
1/2 p90
RSK JNK Chk
1/2 ATM/
ATR ROCK IKK IκB 14.3.3 p53 p53 NF-κB NF-κB Calpain GSK-3β Akt PI3K Caspase
-9 Caspase
-3/6/7 Caspase
-12 Caspase
-8/10 Bcl-XL Bcl-2 Bax Growth
Factors Apoptosis
Receptor Raf Ras IAP IAP AIF MEK
1/2 ERK
1/2 p90
RSK JNK Chk
1/2 ATM/
ATR ROCK IKK IκB 14.3.3 p53 p53 NF-κB NF-κB Calpain GSK-3β Akt PI3K Caspase
-9 Caspase
-3/6/7 Caspase
-12 Caspase
-8/10 Bcl-XL Bcl-2 Bax Growth
Factors Apoptosis
Apoptosis is defined as a mechanism of cell death which occurs after sufficient cellular damage. It is a method of cellular death that is orchestrated by the cell itself and leads to their removal with no subsequent inflammation or stress. Apoptosis occurs during development and ageing and is a vital component of cell turnover.
Questions? Comments? Leave feedback.
Signaling Pathway Key
Stimulates
Inhibits
Multistep Activation
Upregulates
Translocates
Multistep Upregulation
Kinase
Transcription Factor
Enzyme-linked Receptor
Other Enzyme
Other Protein
Proapoptotic
Prosurvival
