6877002

Cat. No. 5602 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： CD40-TRAF6 interaction inhibitor

化学名： 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one

纯度： ≥99% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 6877002

6877002 is a CD40-TRAF6 interaction inhibitor. Suppresses CD40-induced IL-1β and IL-6 expression in macrophages in vitro. Improves insulin sensitivity, reduces adipose tissue inflammation, and ameliorates hepatosteatosis in diet-induced obese mice.

技术数据 for 6877002

分子量	251.32
公式	C₁₇H₁₇NO
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	433249-94-6
PubChem ID	2291556
InChI Key	SARYOFMRLSHZFE-ZHACJKMWSA-N
Smiles	CC1=CC=C(C)C(N/C=C/C(C2=CC=CC=C2)=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 6877002

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	25.13	100
	ethanol	25.13	100

制备储备液 for 6877002

以下数据基于产品分子量 251.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.98 mL	19.89 mL	39.79 mL
5 mM	0.8 mL	3.98 mL	7.96 mL
10 mM	0.4 mL	1.99 mL	3.98 mL
50 mM	0.08 mL	0.4 mL	0.8 mL

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产品说明书 for 6877002

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 6877002

参考文献是支持产品生物活性的出版物。

Chatzigeorgiou et al (2014) Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated Ins resistance. Proc.Natl.Acad.Sci.U.S.A. 111 2686 PMID: 24492375

If you know of a relevant reference for 6877002, please let us know.

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关键词: 6877002, 6877002 supplier, cd40, traf6, tnfalpha, tnfa, tnfα, superfamily, cytokines, receptors, inhibitors, inhibits, inflammation, obesity, diabetes, insulin, Cytokine, Receptors, 5602, Tocris Bioscience

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