6bK

Cat. No. 5402 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Insulin degrading enzyme (IDE) inhibitor

化学名： (3R,6S,9S,12E,16S)-9-(4-Aminobutyl)-3-[(4-benzoylphenyl)methyl]-6-(cyclohexylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,15-pentaazacycloeicos-12-ene-16-carboxamide

纯度： ≥95% (HPLC)

文献 (2)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 6bK

6bK is an insulin degrading enzyme (IDE) inhibitor (IC₅₀ = 50 nM); regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model.

This compound is supplied in net weight as the TFA salt.

许可信息

Sold for research purpose under license from Harvard University

技术数据 for 6bK

分子量	757.92
公式	C₄₁H₅₅N₇O₇
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	1417537-93-9
PubChem ID	91758793
InChI Key	BHZABWWULWHRIY-JAXGQCOVSA-N
Smiles	NC([C@@H](NC(/C=C/C(N[C@@H](CCCCN)C(N[C@H](C(N3)=O)CC2CCCCC2)=O)=O)=O)CCCCNC([C@H]3CC1=CC=C(C(C4=CC=CC=C4)=O)C=C1)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 6bK

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	1	2

制备储备液 for 6bK

以下数据基于产品分子量 757.92。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.02 mM	65.97 mL	329.85 mL	659.7 mL
0.1 mM	13.19 mL	65.97 mL	131.94 mL
0.2 mM	6.6 mL	32.99 mL	65.97 mL
1 mM	1.32 mL	6.6 mL	13.19 mL

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产品说明书 for 6bK

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 6bK

参考文献是支持产品生物活性的出版物。

Maianti et al (2014) Anti-diabetic activity of Ins-degrading enzyme inhibitors mediated by multiple hormones. Nature 511 94 PMID: 24847884

If you know of a relevant reference for 6bK, please let us know.

按标靶查看相关产品

关键词: 6bK, 6bK supplier, Insulin, degrading, enzymes, IDE, inhibitors, inhibits, glucagon, amylin, glucose, tolerance, diabetic, diabetes, and, insulin-like, Receptors, Insulin-like, Other, Proteases, Hydrolases, 5402, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Peptides Involved in Appetite Modulation Scientific Review

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Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for 6bK

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.

6bK