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Submit ReviewThis ligand has uniquely high affinity and selectivity for the D3 receptor. 8-Hydroxy-PIPAT maleate (Cat. No. 0797) also available.
Sold with the permission of the University of Pennsylvania
分子量 | 487.33 |
公式 | C16H22INO.C4H4O4 |
储存 | Desiccate at +4°C |
纯度 | ≥98% (HPLC) |
CAS Number | 200722-46-9 |
PubChem ID | 24978534 |
InChI Key | IQRDHLSQXOATHD-HBRCEPSSSA-N |
Smiles | OC(=O)\C=C/C(O)=O.CCCN(C\C=C\I)C1CCC2=CC=C(O)C=C2C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Chumpradit et al (1993) Synthesis and optical resolution of (R)- and (S)-trans-7-hydroxy-2-[N-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin: a new D3 DA receptor ligand. J.Med.Chem. 36 4308 PMID: 8277513
Foulon et al (1993) Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-amino]tetralin (trans-7-OH-PIPAT): a new D3 DA receptor ligand. J.Med.Chem. 36 1499 PMID: 8098771
Kung et al (1993) In vitro binding of a novel DA D3 receptor ligand: [125I]-trans-7-OH-PIPAT. Eur.J.Pharmacol. 235 165 PMID: 8519278
关键词: 7-Hydroxy-PIPAT maleate, 7-Hydroxy-PIPAT maleate supplier, D3, agonists, Dopamine, Receptors, dopaminergic, 7-OH-PIPAT, 0719, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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