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A 1899

Cat. No. 6972 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker
化学名： N-[(2,4-Difluorophenyl)methyl]-2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl][1,1'-biphenyl]-2-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for A 1899

A 1899 is a potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) channel blocker (IC50 values are 7 nM and 70 nM for human TASK-1 and TASK-3 expressed in CHO cells, respectively). Displays >12.5-fold selectivity for TASK-1 and TASK-3 over other K+ channels (IC50 = 0.9 μM for K2P18.1/TRESK and >2 μM for all other channels tested). Binds within open channel pore.

化合物库 for A 1899

A 1899 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for A 1899

分子量 500.55
公式 C30H26F2N2O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 498577-46-1
PubChem ID 9827303
InChI Key IXKPEYHRIVQTCU-UHFFFAOYSA-N
Smiles COC1=CC=C(C=C1)CC(NCC2=C(C3=C(C(NCC4=C(C=C(C=C4)F)F)=O)C=CC=C3)C=CC=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A 1899

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 50.05 100

制备储备液 for A 1899

以下数据基于产品分子量 500.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2 mL 9.99 mL 19.98 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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参考文献 for A 1899

参考文献是支持产品生物活性的出版物。

Streit et al (2011) A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore. J.Biol.Chem. 286 13977 PMID: 21362619

If you know of a relevant reference for A 1899, please let us know.

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关键词: A 1899, A 1899 supplier, A1899, potassium, channel, two, pore, blockers, blocks, task1, task-1, task3, potent, Two-P, Potassium, Channels, 6972, Tocris Bioscience

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