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A 196

Cat. No. 6167 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective SUV420H1/H2 inhibitor
化学名： 6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for A 196

A 196 is a potent and selective SUV420H1/H2 inhibitor (IC50 values are 25 and 144 nM respectively) that exhibits 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. A 196 inhibits the di- and tri-methylation of H4K20me in multiple cell lines (IC50 < 1 μM).

To request the negative control for A 196, please fill out the SGC 2043 request form on the SGC website.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the A-196 probe summary on the SGC website.

External Portal Information for A 196

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of A196 is reviewed on the Chemical Probes website.

化合物库 for A 196

A 196 is also offered as part of the Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for A 196

分子量 359.25
公式 C18H16Cl2N4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1982372-88-2
PubChem ID 117072548
InChI Key ABGOSOMRWSYAOB-UHFFFAOYSA-N
Smiles ClC1=CC2=C(C(C3=CC=NC=C3)=NN=C2NC4CCCC4)C=C1Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A 196

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 7.18 20

制备储备液 for A 196

以下数据基于产品分子量 359.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 13.92 mL 69.59 mL 139.18 mL
1 mM 2.78 mL 13.92 mL 27.84 mL
2 mM 1.39 mL 6.96 mL 13.92 mL
10 mM 0.28 mL 1.39 mL 2.78 mL

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参考文献 for A 196

参考文献是支持产品生物活性的出版物。

Bromberg et al (2017) The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat.Chem.Biol. 13 317 PMID: 28114273

Scheer et al (2019) A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun. 10 19 PMID: 30604761

Brustel et al (2017) Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication. EMBO J 36 2726 PMID: 28778956

If you know of a relevant reference for A 196, please let us know.

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关键词: A 196, A 196 supplier, A196, methyltransferases, histones, inhibitors, inhibits, HMTs, MLL, leukemia, mll-rearranged, H4K20me, potent, selective, Other, Lysine, Methyltransferases, 6167, Tocris Bioscience

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