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Submit ReviewA 286982
说明： Potent inhibitor of the LFA-1/ICAM-1 interaction
化学名： (2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one
纯度： ≥99% (HPLC)
生物活性 for A 286982
A 286982 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion assays respectively).
化合物库 for A 286982
A 286982 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for A 286982
| 分子量 | 453.55 |
| 公式 | C24H27N3O4S |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 280749-17-9 |
| PubChem ID | 9846729 |
| InChI Key | HTGGAYLWTDOFDK-PKNBQFBNSA-N |
| Smiles | O=C(C)N1CCN(C(/C=C/C2=CC([N+]([O-])=O)=C(SC3=CC=CC=C3C(C)C)C=C2)=O)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for A 286982
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 45.35 | 100 | |
| ethanol | 22.68 | 50 |
制备储备液 for A 286982
以下数据基于产品分子量 453.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.2 mL | 11.02 mL | 22.05 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.41 mL |
| 10 mM | 0.22 mL | 1.1 mL | 2.2 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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产品说明书 for A 286982
参考文献 for A 286982
参考文献是支持产品生物活性的出版物。
Liu et al (2000) Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. J.Med.Chem. 43 4025 PMID: 11052808
If you know of a relevant reference for A 286982, please let us know.
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关键词: A 286982, A 286982 supplier, A286982, LFA-1/ICAM-1, inhibitors, cellular, adhesion, leukocyte, function-associated, antigen-1, inhibits, Integrins, Cell, Adhesion, Molecules, 4228, Tocris Bioscience
1 篇 A 286982 的引用文献
引用文献是使用了 Tocris 产品的出版物。 A 286982 的部分引用包括：
Jon M et al (2019) Approaches for investigating the extracellular signaling function of ISG15. Methods Enzymol 618 211-227 PMID: 30850053
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A 286982 的评论
平均评分: 5 (Based on 1 Review.)
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A 286982 was used to inhibit the action of LFA-1 ( alpha L beta 2) and measure effects.
By
Anonymous on 02/26/2019
种属： Human
alpha L beta 2 is crucial for lymphocyte adhesion and costimulation. We worked to determine alpha L beta 2's role in leukocyte adhesion to and migration through endothelium by its ability to bind intercellular adhesion molecules (ICAMs). A 286982 was used to inhibit the action and measure effects.
该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
