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Submit ReviewA 412997 dihydrochloride
说明： Selective D4 agonist
化学名： N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide
纯度： ≥98% (HPLC)
生物活性 for A 412997 dihydrochloride
A 412997 dihydrochloride is a selective agonist for the dopamine D4 receptor (Ki values are 7.9 and 12.1 nM for human D4 and rat D4 receptors). Displays no affinity (<1000 nM) for other dopamine receptors. Shows efficacy in rat models of ADHD and short-term memory.
化合物库 for A 412997 dihydrochloride
A 412997 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for A 412997 dihydrochloride
| 分子量 | 382.33 |
| 公式 | C19H23N3O.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1347744-96-0 |
| PubChem ID | 90488953 |
| InChI Key | KIGNSSHMCNBHQX-UHFFFAOYSA-N |
| Smiles | O=C(CN2CCC(C3=CC=CC=N3)CC2)NC1=CC=CC(C)=C1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for A 412997 dihydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 38.23 | 100 | |
| DMSO | 19.12 | 50 |
制备储备液 for A 412997 dihydrochloride
以下数据基于产品分子量 382.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.62 mL | 13.08 mL | 26.16 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.23 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.62 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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产品说明书 for A 412997 dihydrochloride
参考文献 for A 412997 dihydrochloride
参考文献是支持产品生物活性的出版物。
Browman et al (2005) A-412997, a selective DA D4 agonist, improves cognitive performance in rats. Pharmacol.Biochem.Behav. 82 148 PMID: 16154186
Patel et al (2006) Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable DA D4 agonist for the treatment of erectile dysfunction. J.Med.Chem. 49 7450 PMID: 17149874
Moreland et al (2005) A-412997 is a selective DA D4 receptor agonist in rats. Pharmacol.Biochem.Behav. 82 140 PMID: 16153699
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关键词: A 412997 dihydrochloride, A 412997 dihydrochloride supplier, A412997, selective, agonists, dopamine, dopaminergic, d4, D4, Receptors, 4552, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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