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Submit ReviewA 582941
说明： α7 nAChR partial agonist
化学名： Octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole
纯度： ≥98% (HPLC)
生物活性 for A 582941
A 582941 is a selective α7 nAChR partial agonist; exhibits high affinity for both rat and human α7 receptors (Ki values are 10.8 and 16.7 nM respectively). Displays ~15-fold selectivity for α7 over 5-HT3 receptors (Ki = 150 nM for 5-HT3).
技术数据 for A 582941
| 分子量 | 280.37 |
| 公式 | C17H20N4 |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 848591-90-2 |
| PubChem ID | 44190553 |
| InChI Key | GTMRUYCIJSNXGB-GASCZTMLSA-N |
| Smiles | [H][C@@]12[C@@](CN(C3=CC=C(C4=CC=CC=C4)N=N3)C2)([H])CN(C)C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for A 582941
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 28.04 | 100 | |
| 1eq. HCl | 14.02 | 50 |
制备储备液 for A 582941
以下数据基于产品分子量 280.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.57 mL | 17.83 mL | 35.67 mL |
| 5 mM | 0.71 mL | 3.57 mL | 7.13 mL |
| 10 mM | 0.36 mL | 1.78 mL | 3.57 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.71 mL |
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产品说明书 for A 582941
参考文献 for A 582941
参考文献是支持产品生物活性的出版物。
Anderson et al (2008) [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity α7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain J.Pharmacol.Exp.Ther. 324 179 PMID: 17959745
If you know of a relevant reference for A 582941, please let us know.
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关键词: A 582941, A 582941 supplier, A582941, selective, alpha7, α7, a7, nicotinics, receptors, partial, agonists, Nicotinic, (a7), Receptors, 4341, Tocris Bioscience
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